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Klappentext The Medicinal Chemist's Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual "table-of-contents" style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist's Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry. Zusammenfassung The Medicinal Chemist’s Guide to Solving ADMET Challenges presents state-of-the-art design strategies by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry. Inhaltsverzeichnis Solubility; Efflux transporters; Cytochrome P450 metabolism; Cytochrome P450 induction; Cytochrome P450 inhibition; Aldehyde & xanthine oxidase metabolism; Reactive metabolites; Phototoxicity; Glucuronidation & sulfation; Phospholipidosis; hERG potassium channel inhibition; Genotoxicity; Sodium & calcium channel inhibition; Passive Permeability; Uptake Transporters in the GI; Organic anion and cation transporters from the SLC22 and SLCO families; Bile salt export pump inhibition;
