Viral Infections of Humans - Epidemiology and Control

also occurs. New outbreaks of yellow fever have occurred in Colombia and Trinidad and new outbreaks of rift valley fever have occurred in Egypt. Chapter 6, Arenaviruses: The biochemical and physical properties have now been clar ified, and they show a remarkable uniformity in the various viruses constituting the group. The possibility that prenatal infection with LCM may result in hydrocephalus and chorioretinitis has been raised. Serologic surveys have suggested the existence of Lassa virus infection in Guinea, Central African Empire, Mali, Senegal, Cameroon, and Benin, in addition to earlier identification in Nigeria, Liberia, and Sierra Leone. Chapter 7, Coronaviruses: New studies have confirmed the important role of these viruses in common respiratory illnesses of children and adults. The viruses are now known to contain a single positive strand of RNA. About 50% of corona virus infections result in clinical illness. About 5% of common colds are caused by strain DC 43 in winter. Chapter 8, Cytomegalovirus: Sections on pathogenesis of CMV in relation to organ transplantation and mononucleosis, as well as sections on the risk and features of con genital infection and disease, have been expanded. There are encouraging preliminary results with a live CMV vaccine, but the questions of viral persistence and oncogenicity require further evaluation.

List of contents

I. Introduction and Concepts.- 1 Epidemiological Concepts and Methods.- 1. Introduction.- 2. Definitions and Methods.- 3. Epidemics.- 4. Investigation of an Epidemic.- 5. The Agent.- 6. The Environment.- 7. The Host.- 8. Routes of Transmission.- 8.1. Respiratory.- 8.2. Gastrointestinal.- 8.3. Skin.- 8.4. Genital.- 8.5. Intrauterine or Transplacental.- 8.6. Genitourinary.- 8.7. Personal Contact.- 8.8. Water and Food.- 8.9. Arthropod-Borne.- 9. Pathogenesis.- 9.1. Respiratory.- 9.2. Gastrointestinal.- 9.3. Systemic Infections.- 9.4. The Exanthem.- 9.5. Infections of the Central Nervous System.- 9.6. Persistent Viral Infections.- 10. Incubation Period.- 11. The Immune Response.- 11.1. Humoral Immunity.- 11.2. Local Immunity (Secretory IgA System).- 11.3. Cell-Mediated Immunity.- 11.4. Immune Responses in the Pathogenesis of Viral Diseases.- 12. Patterns of Host Responses.- 12.1. The Biological Gradient.- 12.2. Clinical Syndromes.- 13. Diagnosis of Viral Diseases.- 13.1. Collection.- 13.2. Requests for Testing.- 13.3. Tests Employed.- 13.4. Interpretation of Tests.- 14. Proof of Causation.- 15. Control and Prevention.- 15.1. Immunization.- 15.2. Chemoprophylaxis and Therapy.- 16. References.- 17. Suggested Reading.- 2 Surveillance and Seroepidemiology.- 1. Introduction.- 2. Surveillance.- 2.1. Historical Background.- 2.2. Elements of Surveillance.- 2.3. Other Surveillance Methods.- 2.4. Surveillance in Research Studies.- 2.5. Publications on Surveillance.- 2.6. Predictive Surveillance.- 3. Seroepidemiology.- 3.1. Introduction.- 3.2. Historical Background.- 3.3. Methodology.- 3.4. Advantages and Limitations.- 3.5. Uses of Seroepidemiology.- 4. References.- II. Acute Viral Infections.- 3 Adenoviruses.- 1. Introduction.- 2. Historical Background.- 3. Methodology Involved in Epidemiological Analysis.- 3.1. Sources of Data.- 3.2. Interpretation of Laboratory Tests.- 4. Characteristics of the Virus.- 5. Descriptive Epidemiology.- 5.1. Synopsis of Descriptive Epidemiology.- 5.2. Epidemiological and Clinical Aspects of Specific Syndromes.- 6. Mechanisms and Route of Transmission.- 7. Pathogenesis and Immunity.- 8. Patterns of Host Response.- 9. Control and Prevention.- 10. Unresolved Problems.- 11. References.- 12. Suggested Reading.- 4 African Hemorrhagic Fevers Due to Marburg and Ebola Viruses.- 1. Introduction.- 2. Historical Background.- 3. Methodology Used in Epidemiological Analysis.- 3.1. Sources of Morbidity and Mortality Data.- 3.2. Laboratory Diagnosis.- 3.3. Surveys.- 3.4. Clinical Diagnosis of Acute Infection.- 4. Characteristics of Marburg and Ebola Viruses.- 4.1. Morphology and Morphogenesis.- 4.2. Physical Properties.- 4.3. Chemical Properties.- 4.4. Biological Properties.- 4.5. Serological Relationships.- 5. Descriptive Epidemiology.- 5.1. Prevalence and Incidence.- 5.2. Epidemic Behavior and Contagiousness.- 5.3. Other Epidemiological Features.- 6. Mechanism and Route of Transmission.- 6.1. Spread of Virus.- 6.2. Reservoir.- 7. Pathogenesis and Immunity.- 7.1. In Guinea Pigs and Hamsters.- 7.2. In Nonhuman Primates.- 7.3. In Man.- 8. Patterns of Host Response.- 8.1. Clinical Features.- 8.2. Diagnosis.- 9. Prevention and Control.- 9.1. General Concepts.- 9.2. Management and Disposition of Patients.- 9.3. General Strategy for Isolation and Management of Suspect "Exotic" Infections.- 10. Unresolved Problems: Detection of Infection and Disease.- 11. References.- 12. Suggested Reading.- 5 Arboviruses.- 1. Introduction.- 2. Historical Background.- 3. Methodology Involved in Epidemiolgical Analysis.- 3.1. Sources of Mortality Data.- 3.2. Sources of Morbidity Data.- 3.3. Serological Surveys.- 3.4. Laboratory Methods.- 4. Biological Charactristics of the Virus That Affect the Epidemiological Pattern.- 5. Epidemiology.- 5.1. Incidence and Prevalence.- 5.2. Epidemic Behavior.- 5.3. Geographic Distribution.- 5.4. Temporal Distribution.- 5.5. Age and Sex.- 5.6. Other Factors.- 6. Mechanism and Route of Transmission.- 7. Pathogenesis a

Product details

• Assisted by: Alfred S. Evans (Editor), Alfre S Evans (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Release: 01.01.1985, delayed
• EAN: 9781468447293
• ISBN: 978-1-4684-4729-3
• No. of pages: 720
• Illustrations: 34 SW-Abb., 1 Farbabb.
• Subject: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine