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In this book, brain cholinergic systems are examined by leading authorities drawn from the fields of morphology, immunochemistry, electrophysiology, behaviour, and the study of cognitive disorders. The book covers major aspects of the organization and connectivity of cholinergic systems at the light and electron-microscopic levels, intrinsic electrophysiological properties, and ionic conductances of central cholinergic neurons.
List of contents
PART 1: NEW VISTAS ON THE ASCENDING CHOLINERGIC ACTIVATION: M. Steriade & G. Buzsaki: Parallel activation of thalamic and cortical neurons by brainstem and basal forebrain cholinergic systems; PART 2: MORPHOLOGICAL ORGANIZATION OF CHOLINERGIC SYSTEMS; B.H. Wainer & M.-M. Mesulam: Ascending cholinergic pathways in the rat brain; V.E. Koliatsos, L.E. Martin, & D.L. Price: Efferent organization of the mammalian basal forebrain; D. Fitzpatrick & D. Raczkowski: The morphology of cholinergic projections from the brainstem reticular formation of the lateral geniculate nucleus and other thalamic nuclei in the cat; F. Heft, J. Hartikka, B. Knusel, M.O. LaPlume, & D.C. Mash: Nerve growth factor and cholinergic neurons of the mammalian brain; PART 3: PHYSIOLOGICAL ASPECTS OF CHOLINERGIC SYSTEMS: C.S. Leonard & R.R. Llinas: Electrophysiology of mammalian pedunculopontine and laterodorsal tegmental neurons in vitro: implications for the control of REM sleep; R.W. Green & R.W. McCarley: Cholinergic transmission in the brainstem: implications for behavioural state control; D.A. McCormick: Cellular mechanisms of cholinergic control of necortical and thalamic neuronal excitability; Y. Lamour, M.C. Senut, M.H. Bassant, & P. Dutar: Functional properties of septo-hippocampal neurons; R.T. Richardson & M.R. DeLong: Responses of primate nucleus basalis neurons to water rewards and related stimuli; R.W. Dykes: Acetylcholine and neuronal plasticity in somatosensory cortex; W. Singer: The role of acetycholine in use-dependent plasticity of the visual cortex; D. Pare & M. Steriade: Control of the mammilothalmic axis by brainstem cholinergic laterodorsal tegmental afferents: possible involvement in mnemonic processes; PART 4: DISORDERS WITH COGNITIVE DECLINE: G. Pepeu, P.L. Di Patre, & F. Casamenti: Spontaneous and drug-stimulated recovery of cortical cholinergic function after lesion of the nucleus basalis; V. Bigl, T. Arendt, & D. Biesold: The nucleus basalis of meynert during ageing and in dementing neuropsychiatric disorders; N.J. Woolf & L.L. Butcher: Disdifferentiation of structurally plastic neurons initiates the pathologic cascade of Alzheimer's disease: toward a unifying hypothesis.
Summary
A collection of 16 examinations of brain cholinergic systems, from the standpoints of morphology, immunohistochemistry, electrophysiology, behaviour and cognitive disorders.
