Platelets

Comprehensive and definitive source of state-of-the-art knowledge about platelets Integrates the entire field of platelet biology, pathophysiology, and clinical medicine Written for clinicians, pathologists and scientists by 142 world-renowned experts from 18 countries Completely revised and updated, with 11 new chapters on topics such as platelet glycobiology, the platelet transcriptome, platelet inhibitory receptors, platelet function testing in clinical research trials, therapeutic platelet-rich plasma in wound healing, and new antiplatelet drugs Full color textbook with over 250 illustrations and 15,000 references

List of contents

PART I: Platelet Biology
1. The Evolution of Mammalian Platelets
2. Megakaryocyte Development and Platelet Formation
3. The Structure of Resting and Activated Platelets
4. Platelet Glycobiology and the Control of Platelet Function and Lifespan
5. Platelet Genomics
6. Platelet MicroRNAs
7. The Platelet Transcriptome in Health and Disease
8. The Platelet Proteome
9. Platelet Receptors
10. The Glycoprotein Ib-IX-V Complex
11. GPVI and CLEC-2
12. Integrin ¿IIbß3
13. Protease-Activated Receptors
14. The Platelet P2 Receptors
15. Platelet Inhibitory Receptors
16. Interactions Between Platelets, Leukocytes, and the Endothelium
17. Inhibition of Platelet Function by the Endothelium
18. Platelet Signal Transduction
19. Platelet Secretion
20. Hemostatic Thrombus Formation in Flowing Blood
21. Interactions Between Platelets and the Coagulation System
22. Platelet-Derived Extracellular Vesicles
23. Regulation of Fibrinolysis by Platelets
24. The Role of Platelets in Angiogenesis
25. Platelet Function in the Newborn
PART II: The Role of Platelets in Disease
26. The Role of Platelets in Atherothrombosis
27. The Role of Platelets in Diabetes Mellitus
28. The Role of Platelets in Inflammation
29. The Role of Platelets in Antimicrobial Host Defense
30. The Role of Platelets in Tumor Growth, Metastasis, and Immune Evasion
31. The Role of Platelets in Sickle Cell Disease
PART III: Clinical Tests of Platelet Function
32. Platelet Counting
33. Clinical Tests of Platelet Function
34. Platelet Aggregation
35. Flow Cytometry
36. Laboratory Monitoring of Antiplatelet Therapy
37. Platelet Function Testing in Clinical Research Trials
PART IV: Disorders of Platelet Number and/or Function
38. The Clinical Approach to Disorders of Platelet Number and Function
39. Immune Thrombocytopenia (ITP)
40. Drug-Induced Thrombocytopenia
41. Heparin-Induced Thrombocytopenia
42. Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndromes
43. Thrombocytopenia in Pregnancy
44. Thrombocytopenia in the Newborn
45. Alloimmune Thrombocytopenia
46. Inherited Thrombocytopenias
47. Thrombocytosis and Essential Thrombocythemia
48. Inherited Disorders of Platelet Function
49. Acquired Disorders of Platelet Function
PART V: Antiplatelet Therapy
50. Aspirin
51. P2Y12 Antagonists
52. ¿IIbß3 (GPIIb-IIIa) Antagonists
53. PAR-1 Antagonists
54. Phosphodiesterase Inhibitors
55. Novel Antiplatelet Therapies
56. Antiplatelet Drugs in the Management of Coronary Artery Disease
57. Antiplatelet Drugs in the Management of Cerebral Ischemia
58. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Peripheral Artery Disease
59. Antiplatelet Drugs in the Management of Venous Thromboembolism, Cardioembolism, Ventricular Assist Devices, and Pregnancy Complications
60. Antiplatelet Drugs in the Management of Thrombotic/Ischemic Events in Children
PART VI: Therapy to Increase Platelet Numbers and/or Function
61. Thrombopoietin Receptor Agonists
62. Desmopressin (DDAVP)
63. Factor VIIa
64. Platelet Transfusion Medicine
65. Therapeutic Platelet-Rich Plasma in Wound Healing
66. Stem Cell-Derived Platelets
67. Gene Therapy for Platelet Disorders

About the author

Dr. Michelson is Professor of Pediatrics and Professor of Medicine at Harvard Medical School in Boston, Massachusetts, U.S.A. He is also the Director of the Center for Platelet Research Studies (www.platelets.org) and the Director of the Thrombosis and Anticoagulation Program at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. After receiving his medical degree with honors from the University of Adelaide, Australia, Dr. Michelson continued his medical and research training on a Fulbright Scholarship at Boston Children’s Hospital, Brigham and Women’s Hospital, and Harvard Medical School. In 2019 he received the International Society on Thrombosis and Haemostasis (ISTH) Esteemed Career Award. Dr. Michelson has been an invited participant in numerous National Institutes of Health working groups, international workshops and consensus conferences. He is the co-organizer and co-chair of the biennial International Platelets Symposium. Dr. Michelson is a past Chairman of the Platelet Physiology Scientific Subcommittee of the ISTH. He has published more than 450 original research articles, original research abstracts, and invited reviews – nearly all on the topic of platelets. Dr. Michelson has been the principal investigator on more than 100 research grants. He has been an invited speaker at over 200 major medical conferences worldwide. Dr. Michelson is an inventor on two awarded and three provisional U.S. patents.Marco Cattaneo is Professor of Internal Medicine and Director of the Unit of Internal Medicine at Ospedale San Paolo, Università degli Studi di Milano, Italy. After gaining his MD at the Università degli Studi di Milano in 1975, he specialized in Clinical and Laboratory Haematology at the Università degli Studi di Pavia, followed by a Residency at the A. Bianchi Bonomi Haemophilia and Thrombosis Centre and Institute of Internal Medicine at the Ospedale Maggiore, Università degli Studi di Milano. He has been Post-Doctoral Fellow at McMaster University, Hamilton, Ontario and Guest or Visiting Scientist at McMaster University, Hamilton, Ontario, Temple University, Philadelphia and The Scripps Research Institute, La Jolla, California. In 2001 he was awarded the International Society on Thrombosis and Haemostasis (ISTH) 10th Biennial Award for Contributions to Haemostasis and Thrombosis. He has been Editor of Thrombosis Research and on the Editorial Board/Advisory Board for a number of other high-tier journals, including Jornal of Thrombosis and Haemostasis, Haematologica, Platelets, Thrombosis and Haemostasis and Arteriosclerosis, Thrombosis and Vascular Biology. He was Chair of the Working Party on Platelet Aggregation, and Chair of the Scientific Subcommittee on Platelet Physiology, Scientific and Standardization Committee, ISTH. He was a member of the Council of the ISTH from 2010 through 2016. He was President-Elect, President and Past-President of SISET, the Italian Society on thrombosis and hemostasis, in the years 2002-2008. His main research interests focus on pathophysiology of primary haemostasis, pharmacology of antiplatelet agents and the role of homocysteine in thrombotic disease.Dr. Andrew L. “Larry” Frelinger is Assistant Professor of Pediatrics at Harvard Medical School and Associate Director of the Center for Platelet Research Studies (www.platelets.org) and Staff Scientist at Boston Children’s Hospital in Boston, Massachusetts, U.S.A. He received his Ph.D. from Case Western Reserve University in 1986, and began his work on platelets at the Scripps Research Institute, La Jolla, California, in the laboratory of Dr. Mark Ginsberg. Between 1993 and 1998 Dr. Frelinger worked in positions of increasing responsibility in the biotechnology industry. He returned to academia in 1998 as Associate Director of the Center for Platelet Function Studies and Research Associate Professor of Pediatrics at the University of Massachusetts Medical School, Worcester, Massachusetts. In 2009 Dr. Frelinger moved to his current position at Boston Children’s Hospital and Harvard Medical School. He is Co-Chair of the Platelet Physiology Scientific Subcommittee of the International Society on Thrombosis and Haemostasis and first author of the subcommittee’s position statement on monitoring of P2Y12 inhibitors. Dr. Frelinger is Principal Editor for the journal Platelets, has published more than 100 peer-reviewed original research articles, and is an inventor on three awarded and three provisional U.S. patents.Peter Newman is the Vice President for Research and Associate Director of the BloodCenter’s 125 person Blood Research Institute. Dr. Newman’s major research accomplishments include elucidation of the molecular basis of the major human platelet alloantigen systems, including the PlA1/PlA2 polymorphism, the discovery of PECAM-1, and numerous contributions to the understanding of the role of activating and inhibitory receptors that control platelet activation. Dr. Newman has published more than 175 original research articles, book chapters and reviews on the subject of platelet and endothelial cell biology, cell adhesion, and signal transduction. Current research activities include the structural biology of PECAM-1, the role of PECAM-1 in endothelial cell junctional integrity, and novel applications of CRISPR/Cas9 gene editing technology to modify platelet- and megakaryocyte-specific alloantigens in induced pluripotent stem (iPS) cells.

Professionally, Dr. Newman served on the Executive Committee of the Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) Council of the American Heart Association (AHA) from 1999-2004, chaired its Annual Meeting in 2004 and served on its Council from 2010-2012. He chaired the Hemostasis Gordon Conference in 2008, served from 2006-2014 as a member of the American Society of Hematology (ASH) Government Affairs Committee that meets annually with members of Congress, and is a current member of the ASH Audit and Investment Committee. Dr. Newman has been on the editorial board of Blood, has reviewed dozens of grants for both the NIH and the AHA, and currently serves the AHA as Associate Editor of the platelet and thrombosis section of the journal ATVB. He was an Established Investigator of the AHA from 1992-1997, and received a Special Recognition Award from their ATVB Council in 2001. Dr. Newman received an Investigator Recognition Medal from the International Society of Thrombosis (ISTH) in 1997, the Emil von Behring Award from the German Society for Transfusion Medicine in 2007, the E.T.S. Walton Award from Science Foundation of Ireland for his studies on the Molecular Mechanisms of Platelet Activation and Adhesion in 2008, and a Distinguished Career Award from the ISTH in 2013. He recently received a seven-year Outstanding Investigator award from the National Heart Lung and Blood Institute of the National Institutes of Health that supports the majority of his current research program.

Product details

• Authors: Alan Michelson, Alan D. (EDT)/ Cattaneo Michelson
• Assisted by: Marco Cattaneo (Editor), Marco (Dipartimento di Scienze della Salute Cattaneo (Editor), Cattaneo Marco (Editor), Andrew Frelinger (Editor), Andrew (Assistant Professor of Pediatrics Frelinger (Editor), Alan D Michelson (Editor), Alan D. Michelson (Editor), Alan D. (Professor of Pediatrics and Professor of Medicine Michelson (Editor), Michelson Alan D. (Editor), Peter Newman (Editor), Peter (Vice President for Research Newman (Editor), Newman Peter (Editor)
• Publisher: Academic Press London
• Languages: English
• Product format: Hardback
• Released: 31.12.2019
• EAN: 9780128134566
• ISBN: 978-0-12-813456-6
• No. of pages: 1400
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; SCIENCE / Life Sciences / General, MEDICAL / Hematology, Haematology