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Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate normal mammary gland homeostasis in humans, with particular emphasis on the roles of estrogen, progesterone, and growth factors. Comprehensive and up-to-date, Endocrine Oncology offers both basic and clinical researchers not only the latest molecular and cellular findings on endocrine cancers, but also a powerful critical analysis that will prove invaluable to all endocrinologists and oncologists working in the area today.
List of contents
1 Estrogen Receptor in Mammary Gland Physiology.- 2 Multiple Facets of Estrogen Recptor in Human Breast Cancer.- 3 Progesterone Receptors in Normal and Neoplastic Breast.- 4 Pathogenesis of Estrogen Receptor-Positive and -Negative Breast Cancer.- 5 Regulation of EGFR and ERBB2 Expression by Estrogen Receptor in Breast Cancer.- 6 Tamoxifen and Other Antiestrogens in Prevention and Therapy of Breast Cancer.- 7 Prolactin in Human Breast Cancer Development.- 8 Human Chorionic Gonadotropin in Breast Cancer Prevention.- 9 Epidermal Growth Factor-Related Peptides in Endocrine Neoplasias.- 10 Insulin-Like Growth Factors and Endocrine Neoplasia.- 11 Insulin-Like Growth Factor Binding Proteins in Endocrine-Related Neoplasia.- 12 Fibroblast Growth Factors and Their Receptors in Breast and Prostate Cancer.- 13 Steroid Receptors in Prostate Cancer Development and Progression.- 14 Type I Family Growth Factor Receptors and Their Ligands in Prostate Cancer.- 15 Hormonal Manipulation of Prostate Cancer.- 16 Endocrinology of Epithelial Ovarian Cancer.- 17 Molecular Pathogenesis of Endometrial Cancer: The Role of Tamoxifen.- 18 Structure and Function of BRCA Genes.- 19 Role of Apoptosis and its Modulation by Bc1-2 Family Members in Breast and Prostate Cancer.- 20 Transcriptional Coactivators in Cancer.
Summary
Comprehensive and up-to-date, Endocrine Oncology offers both basic and clinical researchers not only the latest molecular and cellular findings on endocrine cancers, but also a powerful critical analysis that will prove invaluable to all endocrinologists and oncologists working in the area today.
Report
"...the reader will find plenty of information on epidermal growth factor-related peptides in endocrine neoplasia...All the contributions are of excellent scientific quality and the authors are recognized experts in their fields....The chapter on tamoxifen and other antiestrogens in the prevention and treatment of breast cancer is one of the more clinically oriented, and is very clearly written and practical....This book will be useful as a reference book, mainly to those who have a strong research interest in the field of breast and/or prostate cancer and those who need an update on molecular advances in a particular field of endocrine oncology." - Annals of Oncology
"...this a timely book, written by an international team....A well illustrated, well written, and informative volume." - Journal of Pediatric Endocrinology and Metabolism
"...presents an integrated overview and state-of-the-art of the most clinical developments concerning breast and prostate cancer. It may be therefore become an invaluable resource for clinicians to update their knowledge about breast and prostate cancer, but also for basic scientists who want to extend their knowledge about the clinical aspect of these cancer diseases." -Cell Biology International
