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Population genomics is a rapidly emerging field that has the potential to transform our understanding of how evolutionary forces shape genomic diversity among microbes. There have already been considerable advances in understanding gene flow and spread of adaptive traits, and in linking epidemiology with evolutionary biology. The current challenge is to find unifying evolutionary principles for organisms that display a wide range of reproductive biology - from highly clonal to promiscuous - and for which the vast majority have eluded cultivation. This requires interdisciplinary approaches that incorporate novel computational tools, testing of existing and novel population genetic models, and creative new ways of linking genetic diversity to ecological factors. This pioneering book will discuss the advances made and promises of population genomics in microorganisms, outlining some of the key theoretical and practical challenges for microbial population genomics, including defining and identifying populations, genomics-based reverse ecology and building appropriate tools to understand microbes in a variety of complex environments.
List of contents
Part 1. Concepts and Approaches.- Chapter1. Computational Methods in Microbial Population Genomics.- Chapter2. What Microbial Population Genomics has taught us about Speciation.- Chapter3. Peering into the genetic makeup of natural microbial populations using metagenomics.- Chapter4. A reverse ecology framework for bacteria and archaea.- Part2. Population genomics of bacteria and archaea.- Chapter5. What is a Pseudomonas syringae Population?.- Chapter6. An introductory narrative to the population genomics of pathogenic bacteria, exemplified by Neisseria meningitidis.- Chapter7. Population genomics of archaea: Signatures of archaeal biology from natural populations.- Part3. Population genomics of fungi.- Chapter8. Advances in Genomics of Human Fungal Pathogens.- Chapter9. Yeast population genomics goes wild: The case of Saccharomyces paradoxus.- Part4. Population genomics of viruses.- Chapter10. Population genomics of plant viruses.- Chapter11. Population genomics of human viruses.- Chapter12. Population genomics of bacteriophages.
About the author
Dr. Martin PolzDepartment of Civil and Environmental EngineeringMassachusetts Institute of TechnologyCambridge, MAUSADr. Om P. RajoraProfessorUniversity of New BrunswickFredericton, NB E3C 5A3Canada
Summary
Population genomics is a rapidly emerging field that has the potential to transform our understanding of how evolutionary forces shape genomic diversity among microbes. There have already been considerable advances in understanding gene flow and spread of adaptive traits, and in linking epidemiology with evolutionary biology. The current challenge is to find unifying evolutionary principles for organisms that display a wide range of reproductive biology – from highly clonal to promiscuous – and for which the vast majority have eluded cultivation. This requires interdisciplinary approaches that incorporate novel computational tools, testing of existing and novel population genetic models, and creative new ways of linking genetic diversity to ecological factors. This pioneering book will discuss the advances made and promises of population genomics in microorganisms, outlining some of the key theoretical and practical challenges for microbial population genomics, including defining and identifying populations, genomics-based reverse ecology and building appropriate tools to understand microbes in a variety of complex environments.
