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Informationen zum Autor Muntaser E. Ibrahim is a Professor at the Department of Molecular Biology, Institute of Endemic Diseases at the University of Khartoum, Sudan. He established the Unit of Diseases and Diversity at the University in 1998. He is a founding member of the African Society of Human Genetics and, in 2014, won the CNR Rao Prize for Scientific Research. Charles Rotimi is the Chief of the Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch and the Director of the Center for Research on Genomics and Global Health at the National Human Genome Research Institute (NIH), Maryland. He was founding president of the African Society of Human Genetics and spearheaded formation of the H3Africa Initiative. Klappentext A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches. Zusammenfassung Biomedical approaches increasingly work with human variation and this volume focuses on Africa! the most genetically diverse continent! and the birthplace of modern humans. It considers population structure and the genetic basis of common infectious and non-communicable diseases in historic and modern contexts! to shed light on human biology. Inhaltsverzeichnis 1. Reflections on conceptualizing Africa for biological studies with a historical component: a small essay Shomarka Omar Y. Keita; 2. History and genetics in Africa: multidisciplinary efforts Shomarka Omar Y. Keita and Muntaser E. Ibrahim; 3. Disease, selection, and evolution in the African landscape Muntaser Ibrahim and Endashaw Bekele; 4. Genetic susceptibility to visceral leishmaniasis Hiba S. Mohamed, Muntaser E. Ibrahim and Jenefer M. Blackwell; 5. Genetics of infection in Sub-Saharan Africa: what can the study of Mendelian immunodeficiency disorders contribute? Melanie Newport; 6. Pharmacogenomics and infectious diseases in Africa: an evolutionary perspective Jennifer L. Baker, Daniel Shriner, Amy R. Bentley and Charles N. Rotimi; 7. A glimpse into pharmacogenomics in Africa Collet Dandara and Alice Matimba; 8. Genomics of cardiometabolic disorders in Sub-Saharan Africa Sally N. Adebamowo, Fasil Tekola-Ayele, Adebowale A. Adeyemo and Charles N. Rotimi; 9. Breast cancer in African populations Konduru S. Sastry and Lotfi Chouchane; 10. Socio-biological transition and cancer: prospects for Africa Sulma Mahmoud, Khalid O. Alfarouk, Ahmed M. Elhassan, Kamal Hamad and Muntaser E. Ibrahim; 11. The genetic epidemiology of orphan diseases in North Africa Lilia Romdhane, Olfa Messaoud, Rym Kefi, Afaf Tiar, Ahlem Amouri, Mourad Mokni, Neji Tebib, Mohamed Zghal, Abdelhamid Barakat, Ahmed Houmeida, Mariem Bozguiya, Mohamed Othman, Ghada El Qameh and Sonia Abdelhak; 12. Birth defects and genetic disease in Sub-Saharan Africa Ambroise Wonkam; 13. Neurogenetic disorders in Africa: hereditary spastic paraplegia: a case study Liena E. O. Elsayed, Ammar E. M. Ahmed and Giovanni Stevanin....
