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Drug action in biological systems is a subject of research as they exert their action by the interactions with different bio-macromolecules. Drug-macromolecular interactions involved in different physiological phenomenon, such as drug transport and anaesthesia. These interactions are generally complex in nature and therefore difficult to understand. Physico-chemical and thermodynamic studies provide information regarding the pattern of drug-macromolecular aggregation. Most of the biochemical processes is temperature dependant and occurs in aqueous media. Therefore thermo physical properties of drug-macromolecular systems in aqueous media at different temperatures provide valuable information in medicinal chemistry. Generally drug molecules contains both hydrophilic and hydrophobic groups hence it exhibits a number of specific and non specific interactions in aqueous media. Volumetric, viscometric and acoustic properties are helpful in understanding these interactions
About the author
Dr. Abhijit Sarkar is an engineer in Indian Oil Corporation by profession and a researcher in the University of North Bengal. He has published 16 research articles and 3 books.Dr. Biswajit Sinha is an associate professor in the University of North Bengal. He has published more than 65 research articles in different reputed journals and 4 books.
