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Informationen zum Autor K. Frank Austen. Astra Zeneca Professor of Respiratory and Inflammatory Diseases Department of Medicine, Emertius Brigham and Women's Hospital Department of Medicine; Division of Rheumatology, Immunology and Allergies. Klappentext The Second edition of Therapeutic Immunology provides a thorough and current review of existing and emerging treatments for diseases of immunologic origin with 14 new chapters and 36 new contributors. Editors and contributors who are recognized leaders in their specialties provide current information on the full spectrum of topics related to intervention, including antibodies, cytokines, gene and cell therapies, and vaccines. The book should prove a valuable reference for all researchers and physicians working in the field of immunologic disease. Practicing clinicians will appreciate the authors' emphasis on the underlying principles behind clinical interventions and discussions of the applications of current research in immunology, molecular biology, and biotechnology. Three sections covering drugs, biologic agents, and maneuvers demonstrate how the latest developments in immunology and biotechnology can provide treatment strategies for many previously incurable diseases. Zusammenfassung Provides a review of existing and emerging treatments for diseases of immunologic origin. This book contains sections covering drugs! biologic agents! and maneuvers which demonstrate how the developments in immunology and biotechnology can provide treatment strategies for incurable diseases. Inhaltsverzeichnis Contributors. Preface. Part I: Introduction. 1. Adaptive Immunity. (Emil R. Unanue). 2. Innate Immunity and Instruction of the Adaptive Immune Response. (Douglas T. Fearon). Part II: Drugs. 3. Cyclophosphamide. (Alfred D. Steinberg). 4. The Purine Antagonists: Azathioprine and Mycophenolate Mofetil. (Nina E. Tolkoff-Rubin and Robert H. Rubin). 5. Methotrexate. (Michael E. Weinblatt). 6. Immunosupression and Immunophilin Binding Agents: Current research and Clinical Applications. (Shairaz Baksh, Jeff Friedman, Steven J. Burakoff, and Barbara E. Bierer). 7. Glucocorticoid Action. (Jeffrey N. Miner and Myles Brown). 8. Cyclooxygenase Inhibitors. (William L. Smith and David L. DeWitt). 9. Antileukotrienes (Leukotriene Modifiers) in the treatment of Asthma. (Jeffrey M. Drazen). 10. Phosphodiesterase Inhibitors. (Nicky Cooper, Mamidipudi Thirumala Krishna, Robrt Gristwood, and Stephen Holgate. 11. Tryptase Inhibitors. (Andrew F. Walls). 12. 5-Aminosalicylic Acid (Mesalamine)and Sulfasalazine. (Richard P. MacDeDermott. 13. Antihistamines (H-Receptor Antagonists). (F. Estelle R. Simons). Part III: Biologic Agents. 14. Hematopoietic Growth Factors. 15. Cytokines Regulating Immune Inflammation: Interleukin-4, Interleukin-10, and Interleukin-12. (Richard N. Mitchell and Abul K. Abbas). 16. The Interferons: Basic Biology and Therapeutic Potential. (Vijay Shankaran and Robert D. Schreiber)'. 17. Interleukin-2 Immunostimulation. (Kendall A. Smith). 18. A Soluble TNF Receptor-FC Fusion Protein (Etanercept) in the Treatment of Inflammatory Diseases. (Michael b. Widmer, Leslie Garrison, and Kendall M. Mohler). 19. Intravenous Immunoglobulin Therapy. (Francisco A. Bonilla and Raif S. Geha). 20. Therapeutic Inhibition of Complement Actiation with Emphasis on Drugs in Clinical Trails. (Lloyd B. Klickstein, Francis D. Moore, Jr., and John P. Atkinson). 21. Treatment of Angioedema Resulting from C1-Inhibitor Deficiency. A. Thomas Waytes and Fred S. Rosen). 22. Inhibitors of Tumor Necrosis Factor. (Arthur F. Kavanaugh and Peter E. Lipsky). 23. Targeting the IL-2 Receptor with Antibodies or Chimeric Toxins. (Terry B. Strom). 24. Mon...
