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This volume discusses experimental brain injury models thatcontain valuable information carefully chosen to widen the researchers' horizonabout neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have beenadapted and made ready for application in laboratory settings. For easiernavigation, the chapters are categorized into 6 parts: Introduction, GeneralConsideration in Using Animal Laboratory in CNS Injury Research, Classical TBIModels and Their Link with Pathophysiological Features of CBS Injury - Models,Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, OutcomeMeasures in Brain Injury Models, and Future Directions. Written in the highly successful Methods inMolecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls.
Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards theprogress of this discipline.
List of contents
The History and Evolution ofExperimental Traumatic Brain Injury Models.- Clinical Traumatic Brain Injury inthe Preclinical Setting.- RodentModels of Traumatic Brain Injury: Methods and Challenges.- TraumaticBrain Injury Models in Animals.- SystematicReview of Traumatic Brain Injury Animal Models.- Methodsof Drug Delivery in Neurotrauma.- Bridgingthe Gap of Standardized Animals Models for Blast Neurotrauma: Methodology for Appropriate Experimental Testing.- CellularMechanisms and Behavioral Outcomes in Blast-Induced Neurotrauma: ComparingExperimental Set-Ups.- Applicationof Systems Biology to Neuroproteomics: The Path to Enhanced Theranostics forTraumatic Brain Injury.- Role of Systems Biology in BrainInjury Biomarker Discovery: A Neuroproteomic Application.- TheControlled Cortical Impact Model of Experimental Brain Trauma: Overview,Research Applications, and Protocol.- WeightDrop Models in Traumatic Brain Injury.- Midline(Central) Fluid Percussion Model of Traumatic Brain Injury.- Lateral(Parasagittal) Fluid Percussion Model of Brain Injury.- ImpactAcceleration Model of Diffuse Traumatic Brain Injury.- ExperimentalModels for Neurotrauma Research.- A Porcine Modelof Traumatic Brain Injury via Head Rotational Acceleration.- PediatricRodent Models of TraumaticBrain Injury.- ModelingPediatric Brain Trauma: Piglet Model of Controlled Cortical Impact.- ThromboembolicModel of Cerebral Ischemia and Reperfusion in Mice.- AnimalStroke Model: Ischemia/Reperfusion and Intracerebral Hemorrhage.- CombinedNeurotrauma Models: Experimental Models Combining Traumatic Brain Injury and SecondaryInsults.- Microdialysis as ClinicalEvaluation of Therapeutic Hypothermia in Rat Subdural Hematoma Model.- Repetitive Transcranial MagneticStimulation as a Novel Therapy in Animal Models of Traumatic Brain Injury.- ExperimentalModels Combining TBI, Hemorrhagic Shock, and Hypoxemia.- ExperimentalModels Combining Traumatic Brain Injury and Hypoxia.- AnimalModels of Post-Traumatic Seizures and Epilepsy.- Closed-HeadTBI Model of Multiple-Morbidity.- CognitiveEvaluation Using Morris Water Maze in Neurotrauma.- Assessmentof Cognitive Function in the Water Maze Task: Maximizing Data Collection and Analysisin Animal Models of Brain Injury.- DetectingBehavioral Deficits Post Traumatic Brain Injury in Rats.- Advancedand High Throughput Method for Mitochondrial Bioenergetics Evaluation inNeurotrauma.- Determinationof Vascular Reactivity of Middle Cerebral Arteries from Stroke and Spinal CordInjury Animal Models Using Pressure Myography.- Assessment of Basilar Artery Reactivityin Stroke and Subarachnoid Hemorrhage Using Wire Myograph.- Magnetic Resonance Imaging in ExperimentalTraumatic Brain Injury.- A Simplified Workflow for ProteinQuantitation of Rat Brain Tissues Using Label-Free Proteomics and SpectralCounting.- Phenotypic Screening of Small-MoleculeInhibitors: Implications for Therapeutic Discovery and Drug Target Developmentin Traumatic Brain Injury.- Postnatal Neural Stem Cells inTreating Traumatic Brain Injury.- A Novel Biopsy Method for IsolatingNeural Stem Cells from the Subventricular Zone of the Adult Rat Brain for AutologousTransplantation in CNS Injuries.- Challenging the Paradigms of ExperimentalTBI Models: From Preclinical to Clinical Practice.
Summary
This volume discusses experimental brain injury models that
contain valuable information carefully chosen to widen the researchers’ horizon
about neurotrauma. Injury Models of Central Nervous System: Methods and Protocols contains relevant experimental design approaches that have been
adapted and made ready for application in laboratory settings. For easier
navigation, the chapters are categorized into 6 parts: Introduction, General
Consideration in Using Animal Laboratory in CNS Injury Research, Classical TBI
Models and Their Link with Pathophysiological Features of CBS Injury – Models,
Special Topics in CNS Trauma: Comorbid Conditions in CNS Injury, Outcome
Measures in Brain Injury Models, and Future Directions. Written in the highly successful Methods in
Molecular Biology series format, chapters include introductions to their
respective topics, lists of the necessary materials and reagents, step-by-step,
readily reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls.
Practical and thorough, Injury Models of Central Nervous Systems: Methods and Protocols, is a very useful reference towards the
progress of this discipline.
