Regenerative Medicine - from Protocol to Patient - 1. Biology of Tissue Regeneration

Regenerative medicine is the main field ofgroundbreaking medical development and therapy using knowledge from developmental andstem cell biology, as well as advancedmolecular and cellular techniques. This collection of volumes on Regenerative Medicine: FromProtocol to Patient, aims to explain the scientific knowledge and emergingtechnology, as well as theclinical application in different organ systems and diseases. Internationalleading experts from all over the world describe the latest scientific andclinical knowledge of the field of regenerative medicine. The process of translatingscience of laboratory protocols into therapies is explained in sections onregulatory,ethical and industrial issues. This collection is organized into five volumes: (1) Biology ofTissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering,Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) RegenerativeTherapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientificbasis, therapeutical protocols, clinical translation and practiced therapies in regenerativemedicine.
Volume 1 contains eleven chapters addressing the latest basic science knowledge on the "Biologyof Tissue Regeneration". The principles of cell regeneration control by extracellularmatrix and the biology of stemcell niches are explained. Depicted are the principles ofmolecular mechanisms controlling asymmetric cell division, stem cell differentiation,developmental and regenerative biology, epigenetic and genetic control as well asmathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissueregeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming areoutlined. These up to date accounts  gives the readers advanced insights into thebiological principles of the regenerative processes in stem cells, tissues andorganisms.

 

List of contents

1 Extracellular matrix and tissue regeneration, Zygmunt Mackiewicz, Yrjö Tapio Konttinen, Emilia Kaivosoja, Vasily Stegajev, Hanoch Daniel Wagner, Jaakko Levón and Veli-Matti Tiainen.- 2 Stem cell niche, Chenhui Wang, Jun Chen, Pei Wen, Pei Sun and Rongwen Xi.- 3 Stem cells and asymmetric cell division, Rita Sousa-Nunes and Frank Hirth.- 4 Stem cells in the developing and adult nervous system, Fumitaka Osakada and Masayo Takahashi.- 5 Epigenetic mechanisms regulating the transition from embryonic stem cells towards a differentiated neural progeny, Marijn Schouten, Nik Papaloukas, Pascal Bielefeld, Silvina A. Fratantoni and Carlos P. Fitzsimons.- 6 Mathematical models in stem cell differentiation and fate predictability, Wayne M. Eby and Natalia Coleman.- 7 Organ and appendage regeneration in the axolotl, Johanna E Farkas, Piril Erler, Polina D Freitas, Alexandra Sweeney, and James R Monaghan.- 8 Development and regeneration of the vertebrate brain, Brian Key.- 9 Role of innate immune signaling in nuclear reprogramming, Shu Meng, Palas Chandaand John P. Cooke.- 10 Cardiac regeneration in zebrafish, Chi-Chung Wu and Gilbert Weidinger.- 11 Genetics and regeneration in vertebrates, Elizabeth Denise Hutchins and Kenro Kusumi.- Index.

About the author

Gustav Steinhoff initiated and leads the Reference and Translation
Center for Cardiac Stem Cell Therapy (RTC) of the University Medical Center
Rostock. He is
known as an expert in the medical field of stem cell therapies and the first
clinician to treat patients with intramyocardial transplantation of purified
stem cells and is one of the pioneers of these new therapies. Besides his
medical study at the Erasmus University Rotterdam, Gustav Steinhoff performed
research at the Baylor College in Houston, Texas. He has worked as a surgeon at
the University of Kiel and the Medical School Hannover, where he was appointed
as an Associate Professor of Cardiothoracic Surgery in 1998.  In 2000 he
moved to the University of Rostock as a Director and Chairman of the Department
of Cardiac Surgery where he continued his research on cardiac stem cell
therapies and tissue engineering.

Summary

Regenerative medicine is the main field of
groundbreaking medical development and therapy using knowledge from developmental and
stem cell biology, as well as advanced
molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From
Protocol to Patient, aims to explain the scientific knowledge and emerging
technology, as well as the
clinical application in different organ systems and diseases. International
leading experts from all over the world describe the latest scientific and
clinical knowledge of the field of regenerative medicine. The process of translating
science of laboratory protocols into therapies is explained in sections onregulatory,
ethical and industrial issues. This collection is organized into five volumes: (1) Biology of
Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering,
Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative
Therapies II. The textbook gives the student, the researcher, the health care professional, 
the physician and the patient a complete survey on the current scientific
basis, therapeutical protocols, clinical translation and practiced therapies in regenerative
medicine.
Volume 1 contains eleven chapters addressing the latest basic science knowledge on the “Biology
of Tissue Regeneration”. The principles of cell regeneration control by extracellular
matrix and the biology of stem
cell niches are explained. Depicted are the principles of
molecular mechanisms controlling asymmetric cell division, stem cell differentiation,
developmental and regenerative biology, epigenetic and genetic control as well as
mathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissue
regeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming are
outlined. These up to date accounts  gives the readers advanced insights into the
biological principles of the regenerative processes in stem cells, tissues and
organisms.

 

Product details

• Assisted by: Gusta Steinhoff (Editor), Gustav Steinhoff (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2018
• EAN: 9783319801773
• ISBN: 978-3-31-980177-3
• No. of pages: 373
• Dimensions: 155 mm x 17 mm x 235 mm
• Weight: 657 g
• Illustrations: XIII, 373 p. 31 illus., 24 illus. in color.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; B, molecular biology, biotechnology, Biomedical and Life Sciences, Materials science, Biomedical Research, Biomaterials, Molecular Medicine, Genetics (non-medical), Stem Cell Biology, stem cells