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Thisthesis gives a thorough account of the development of iron-catalysedhydrosilylation, hydroboration and hydromagnesiation reactions. Withextraordinary referencing and scientific argument, Mark Greenhalgh describesthe development of methodologies which require only commercially availablematerials and non-specialised techniques. The intention of this approach is toensure the science can be adopted widely by the chemical community. In additionto an insight into the processes involved in methodology development, Greenhalghdiscusses and determines the relevant reaction mechanisms. This thesis providesnot only the most thorough review of the area, but offers a level of insightwell beyond that expected from a Ph.D. student. The work in this thesis hasbeen published at the highest level, and the results and ideas have led to 3industry-funded Ph.D. studentships and grant income in excess of £1 million.
List of contents
Introduction.- Iron-Catalysed Hydrosilylation of Alkenes and Alkynes.- Iron-Catalysed Hydroboration of Alkenes and Alkynes.- Iron-Catalysed Hydromagnesiation of Styrene Derivatives.- Experimental.- References
About the author
Mark studied Chemistry with a year in Australia at the University of Sheffield, graduating in 2010 after completing his final year project with Dr Simon Jones. He joined the Chemical Synthesis DTC at the University of Bristol in 2010, and began his PhD the following year with Dr Steve Thomas and Prof. Paul Pringle on iron-catalysed hydrofunctionalisation of alkenes and alkynes. He moved with Steve to the University of Edinburgh in 2012 to complete his PhD studies. Mark has recently moved to St. Andrews to work with Prof. Andrew Smith on the development of Lewis base-catalysed asymmetric methodologies.
Summary
This
thesis gives a thorough account of the development of iron-catalysed
hydrosilylation, hydroboration and hydromagnesiation reactions. With
extraordinary referencing and scientific argument, Mark Greenhalgh describes
the development of methodologies which require only commercially available
materials and non-specialised techniques. The intention of this approach is to
ensure the science can be adopted widely by the chemical community. In addition
to an insight into the processes involved in methodology development, Greenhalgh
discusses and determines the relevant reaction mechanisms. This thesis provides
not only the most thorough review of the area, but offers a level of insight
well beyond that expected from a Ph.D. student. The work in this thesis has
been published at the highest level, and the results and ideas have led to 3
industry-funded Ph.D. studentships and grant income in excess of £1 million.
