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Thisvolume focuses on the roles of long non-coding RNAs (lncRNAs) in contextsranging from human cancers to cardiovascular disease and ageing. The role oflncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, pastretroelements integrated within the human genome, as well as the role thesepseudogene-derived lncRNAs play in cancer development are discussed in detail. Further,the book examines the function of lncRNAs in diseases such as diabetes, in smoothmuscle formation, and in the modulation of nuclear receptors, as well as inconnection with perspectiveson the development ofpersonalized therapeutics. It offers an appealing and insightful resource forscientists and clinicians alike.
List of contents
Understandingthe Complex Circuitry of lncRNAs at the X-inactivation Center and itsImplications in Disease Conditions.- Long Non-coding RNA ANRIL and Polycomb inHuman Cancers and Cardiovascular Disease.- Form and function of exosomeassociated long non-coding RNAs in cancer.- Long Non-coding RNAs in Lung Cancer.-Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease.- Functionallong non-coding RNAs in vascular smooth muscle cells.- Long Non-coding RNAs asTargets and Regulators of Nuclear Hormone Receptors.- Non-codingtranscriptional landscape in human aging.- LncRNAs in stress response.- ExpressionSpecificity of Disease-Associated lncRNAs: towards Personalized Medicine.
About the author
Kevin Morris is an Associate Professor at the Department of Molecular and Experimental Medicine, The Scripps Research Institute in La Jolla, CA, USA. The responsible series editor is Peter K. Vogt, The Scripps Research Institute in La Jolla, CA, USA.
Summary
This
volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts
ranging from human cancers to cardiovascular disease and ageing. The role of
lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past
retroelements integrated within the human genome, as well as the role these
pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further,
the book examines the function of lncRNAs in diseases such as diabetes, in smooth
muscle formation, and in the modulation of nuclear receptors, as well as in
connection with perspectives
on the development of
personalized therapeutics. It offers an appealing and insightful resource for
scientists and clinicians alike.
