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This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy.
Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail.
This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
List of contents
Epidemiology including genetic predisposition.- Clinical Features.- Diagnostic flow cytometry and immunophenotypic classification.- Cytogenetics.- Molecular genetics.- Pharmacology including pharmacokinetics, pharmacodynamics and pharmacogenetics.- Minimal Residual Disease.- Treatment - first line.- Treatment - relapse.- Treatment - new drugs.- Treatment - immune based approaches.- Cellular therapy.- Supportive care.- Developing world perspective.
About the author
Professor Ajay Vora is honorary professor of paediatric haematology at University of Sheffield and consultant paediatric haematologist at Sheffield Children’s Hospital. His daily practice involves the care of children with a variety of malignant and non-malignant blood disorders. He has a special interest in childhood leukaemia and cord blood transplantation. He is chair of the UK NCRI childhood leukaemia sub-group and I-BFM ALL committee. He is chief investigator of childhood and infant ALL clinical trials and is involved with several research projects in this area. He is programme director of the Trent Regional Paediatric Haemopoeitic Stem Cell transplant service.
Summary
This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy.
Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail.
This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Additional text
“The purpose is to provide an in‐depth look at the complex disease of childhood ALL. … a concise resource such as this can be used by many medical professionals such as physicians, advanced practitioners, medical students, and nurses in pediatric oncology. … The information is concise and detailed, which makes it a good resource for expert or advanced practitioners in oncology … .” (Lacie D. Filkins, Doody's Book Reviews, July, 2017)
Report
"The purpose is to provide an in-depth look at the complex disease of childhood ALL. ... a concise resource such as this can be used by many medical professionals such as physicians, advanced practitioners, medical students, and nurses in pediatric oncology. ... The information is concise and detailed, which makes it a good resource for expert or advanced practitioners in oncology ... ." (Lacie D. Filkins, Doody's Book Reviews, July, 2017)
