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This book introduces students tomethods that will help them understand behaviour in terms of cellularcomponents and their interactions in non-intuitive ways, which calls for aninterdisciplinary approach combining mathematical, chemical, computational andbiological strategies. Tibor Ganti was one of the early pioneers whoproposed a theoretical framework to understand living principles in terms ofchemical transformation cycles and their coupling. The twenty-first centurythen brought with it a novel 'systems' paradigm, which shone new light on allprevious work and was accompanied by numerous implications for the way weconceive of chemical and biological complexity today.
This book seeks to equip students totake advantage of any field that investigates living systems. Based on aconceptualisation of science-oriented branches, engineering-oriented branchesand biology as astoundingly complex fields, those structures laden withbiochemical detail encompass a deeper theory unifying our knowledge of designedsystems.
Readers will be pleasantly surprised athow lucidly the topics are presented. The book offers an indispensable resourcefor students and professionals working in systems and synthetic biology or anyof the various related fields of research.
List of contents
1. Computational Proteomics (Debasree Sarkar).- 2. Design Principles, Network architecture and their Analysis Strategies as Applied to Biological Systems (Ahmad Abu Turab).- 3. Structureomics in Systems-Based Drug Discovery (Lumbini).- 4. Biosensors for Metabolic Engineering (Qiang Yan).- 5. Sustainable Assessment on Using Bacterial Platform to Produce High Added Value Products from Berries through Metabolic Engineering (Lei Pei).- 6. Hindrances to the Efficient and Stable Expression of Transgenes in Plant Synthetic Biology Approaches (Ana Perez Gonzalez).- 7. The new Massive Data: mirNomics and its Application to Therapeutics (Mohammad Ahmed).- 8. Microscopy Based Analysis of Cells Interacting with Nanostructures (Raimo Hartmann).- 9. Mathematical Chemodescriptors and Biodescriptors: Background and their Applications in Systems Toxicology (Subhash Basak).
About the author
Shailza Singh is working as Scientist D at National
Centre for Cell Science, Pune. She works in the field of Computational and
Systems Biology wherein she is trying to integrate the action of
regulatory circuits, cross-talk between pathways and the non-linear kinetics of
biochemical processes through mathematical models. The current thrust in her
laboratory is to explore the possibility of network-based drug design and how
rationalized therapies may benefit from Systems Biology. She is the recipient
of RGYI (DBT), DST-Young Scientist and INSA (Bilateral Exchange Programme). She
is the reviewer of various international and national grants funded from
government organizations.
Summary
This book introduces students to
methods that will help them understand behaviour in terms of cellular
components and their interactions in non-intuitive ways, which calls for an
interdisciplinary approach combining mathematical, chemical, computational and
biological strategies. Tibor Ganti was one of the early pioneers who
proposed a theoretical framework to understand living principles in terms of
chemical transformation cycles and their coupling. The twenty-first century
then brought with it a novel ‘systems’ paradigm, which shone new light on all
previous work and was accompanied by numerous implications for the way we
conceive of chemical and biological complexity today.
This book seeks to equip students to
take advantage of any field that investigates living systems. Based on a
conceptualisation of science-oriented branches, engineering-oriented branches
and biology as astoundingly complex fields, those structures laden with
biochemical detail encompass a deeper theory unifying our knowledge of designed
systems.
Readers will be pleasantly surprised at
how lucidly the topics are presented. The book offers an indispensable resource
for students and professionals working in systems and synthetic biology or any
of the various related fields of research.
