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This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.
List of contents
1. Introduction.- 2. DEFINING THE PROBLEM OF HIGH-RISK SCC: Epidemiology and Outcomes of SCC/Scope of The Problem.- 3. The Evidence For Clinical and Histologic Risk Predictors.- 4. Tumor Staging Systems and Prognostic Stratification.- 5. THE SCIENCE OF SCC: Molecular/Genetic Underpinnings of Tumorormation/Progression/Metastasis/Immunosurveillance.- 6. MANAGEMENT: Management of Patients With Multiple Sccs/Field Cancerization.- 7. Management of High-Risk Primary Tumors.- 8. Management of Extensive Local Recurrence/In-Transit Metastasis.- 9. Management of Nodal Metastases.- 10. Management of Widely Metastatic and Unresectable Disease.
About the author
Chrysalyne Schmults, MD, MSCE
Director, Mohs & Dermatologic Surgery Center
Brigham & Women's Hospital
Department of Dermatology
1153 Centre St., Suite 4349
Jamaica Plain, MA 02130, USA
Summary
This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.
Report
"This book explores the immune and epigenetic mechanisms responsible for the development of squamous cell carcinoma. ... The audience is dermatologists and oncologists. ... When faced with a patient with a high-risk squamous cell carcinoma, this is the reference to turn to for the most up-to-date, multidisciplinary approach." (Patricia Wong, Doody's Book Reviews, August, 2016)
