Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling.

List of contents

Au(I)-phosphine series design.- Probing the Protein: Ion Mobility Spectrometry.- Probing Gold: X-ray Absorption Spectroscopy.- Probing Cells: Cytotoxicity Evaluation.- Au(III) series with k²C,N and k²N,N' ligands.- "Dual Probe" X-ray Absorption Spectroscopy.

Summary

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Product details

• Authors: Raphael Enoque Ferraz de Paiva
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2018
• EAN: 9783030008529
• ISBN: 978-3-0-3000852-9
• No. of pages: 151
• Dimensions: 154 mm x 13 mm x 243 mm
• Weight: 440 g
• Illustrations: XXXIX, 151 p. 100 illus., 38 illus. in color.
• Series: Springer Theses; Springer Theses
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Inorganic chemistry; Biochemie, Organische Chemie, B, Immunologie, Immunology, ORGANOMETALLIC CHEMISTRY, ORGANIC CHEMISTRY, Life Sciences, Spektroskopie, Spektrochemie, Massenspektrometrie, Metallorganische Chemie, biochemistry, Chemistry and Materials Science, proteins, mass spectrometry, Spectrum analysis, spectrochemistry, mass spectrometry, Inorganic Chemistry, Bioorganic Chemistry, Protein-Ligand Interactions