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This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome. Further, it highlights the clinical applications of circulating tumor cells for each cancer type and addresses the emerging importance of extracellular vesicular contents, including miRNA, oncogenes and drug resistant factors. As such, it offers a valuable reference guide for cancer researchers, oncologists, clinicians, surgeons, medical students, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.
List of contents
1. Melanoma Biomarkers in Circulation. - 2. Head and Neck Cancer Biomarkers in Circulation. - 3. Lung Cancer Biomarkers in Circulation. - 4. Breast Cancer Biomarkers in Circulation. - 5. Esophageal Cancer Biomarkers in Circulation. - 6. Gastric Cancer Biomarkers in Circulation. - 7. Colorectal Cancer Biomarkers in Circulation. - 8. Hepatocellular Carcinoma Biomarkers in Circulation. - 9. Pancreatic Cancer Biomarkers in Circulation. - 10. Renal Cell Carcinoma Biomarkers in Circulation. - 11. Urothelial Bladder Cancer Biomarkers in Circulation. - 12. Prostate Cancer Biomarkers in Circulation. - 13. Ovarian Cancer Biomarkers in Circulation. - 14. Endometriosis Biomarkers in Body Fluids. - 15. Endometrial Cancer Biomarkers in Circulation. - 16. Cervical Cancer Biomarkers in Circulation. - 17. Endocrine Cancer Biomarkers in Circulation. - 18. Brain Tumor Biomarkers in Circulation.
About the author
Dr. Gabriel D. Dakubo is an Assistant Professor of Molecular Medicine and Human Anatomy in the Division of Medical Sciences at the Northern Ontario School of Medicine. He received his BSc and MBChB degrees from the University of Ghana, followed by the pursuance of a Postdoctoral research fellowship in Molecular Medicine at the Ottawa Hospital Research Institute, Canada. Dr. Dakubo’s passion is in noninvasive deployment of biomarkers for cancer management. While an expert in mitochondrial genetic alterations in cancer, he also has a keen interest in the inter-genomic communications that occur in the cancer cell, as well as the Slaughter’s concept of field cancerization. Dr. Dakubo is well published, and is a reviewer of a number of esteemed journals, including Clinical Cancer Research.
Summary
This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome. Further, it highlights the clinical applications of circulating tumor cells for each cancer type and addresses the emerging importance of extracellular vesicular contents, including miRNA, oncogenes and drug resistant factors. As such, it offers a valuable reference guide for cancer researchers, oncologists, clinicians, surgeons, medical students, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.
