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This book summarizes ourcurrent understanding about the biology and patho-biology of cardiomyocytes anddepicts common techniques for the study of these cells. Thebook is divided into two parts; the first part provides insight into role andfunction of cardiomyocytes under normal conditions and describes embryogenesisand differentiation, in the second part the role of cardiomyocytes in aging anddisease is discussed and cellular responses under stress conditions illustrated.Cardiomyocytes representthe main mass of the heart, and cellular malfunction directly modifies heartfunction leading to subsequent heart failure. As such, cardiomyocytes arecausative involved in the main reasons of heart failure, such as post-infarctremodeling, hypertensive heart disease, idiopathic heart failure, andinteractions with other co-morbidities such as diabetes. On the other hand,cardiomyocytes are necessarily target of therapy. Therefore, a preciseunderstanding of cardiomyocytes biology is a pre-requisite for proper diseasetreatment and evidence based medicine.The book is written forcell biologists, pharmacologists and biomedical researchers specialized incardiac and vascular biology.
List of contents
Cardiomyocytes: Function and Regeneration.- 1.Ways to study the biology of cardiomyocytes.-2.Cardiomyocytes: Function and Regeneration.- 3.Excitation-contraction couplingof cardiomyocytes.- 4.Cardiac metabolism and energetic control.- 5.Endogenousmechanisms for regulating myocardial contractility.- Cardiomyocytes in ageing,disease, and protection.- 6.Growth regulation of cardiomyocytes: Control ofcell size and its role in cardiac hypertrophy.- 7.Protein Degradation inCardiomyocytes - Target Proteins and clinical consequences.- 8.Ischemia andReperfusion.- 9.Mechanisms of cardiac cell death.- 10.Oxidative stress andnitrosative stress.
About the author
Prof. Dr. Klaus-Dieter Schlüter
Institute of Physiology
JLU Giessen
Giessen, Germany
Summary
This book summarizes our
current understanding about the biology and patho-biology of cardiomyocytes and
depicts common techniques for the study of these cells. The
book is divided into two parts; the first part provides insight into role and
function of cardiomyocytes under normal conditions and describes embryogenesis
and differentiation, in the second part the role of cardiomyocytes in aging and
disease is discussed and cellular responses under stress conditions illustrated.
Cardiomyocytes represent
the main mass of the heart, and cellular malfunction directly modifies heart
function leading to subsequent heart failure. As such, cardiomyocytes are
causative involved in the main reasons of heart failure, such as post-infarct
remodeling, hypertensive heart disease, idiopathic heart failure, and
interactions with other co-morbidities such as diabetes. On the other hand,
cardiomyocytes are necessarily target of therapy. Therefore, a precise
understanding of cardiomyocytes biology is a pre-requisite for proper disease
treatment and evidence based medicine.
The book is written for
cell biologists, pharmacologists and biomedical researchers specialized in
cardiac and vascular biology.
