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This volume provides properties, biological function, methods,and approaches for manipulating nAChRs in different organisms. NicotinicAcetylcholine Receptor Technologies guides readers through moleculartechniques and behavioral tests used to investigate nicotinic drugs,chronoamperometry, emerging technologies and methods for the analysis ofnAChRs, single nucleotide polymorphism (SNP), fluorescence techniques, spectralconfocal, allosteric modulators of a7-nAChRs, and a comprehensive evolutionalrelation for most nAChR subunits, in both vertebrate and invertebrate species.Written for the popular Neuromethods series, chapters include thekind of detail and key implementation advice that ensures successful results inthe laboratory.
Authoritative and practical, Nicotinic AcetylcholineReceptor Technologies aims to ensure successful results in thefurther study of this vital field.
List of contents
Analysisof Nicotinic Acetylcholine Receptor (nAChR) Gene Expression in the Zebrafish (Daniorerio)by In Situ Hybridization and PCR.- Zebrafish:An Animal Model to Study Nicotinic Drugs on Spatial Memory and VisualAttention.- ConditionedPlace Preference and Behavioral Analysis to Evaluate Nicotine ReinforcementProperties in Zebrafish.- Study of theContribution of Nicotinic Receptors to the Release of Endogenous BiogenicAmines in Drosophila Brain.- Emerging Technologiesin the Analysis of C. Elegans NicotinicAcetylcholine Receptors.-Using Natural GeneticVariability in Nicotinic Receptor Genes to Understand the Function of NicotinicReceptors.- Nicotinic Acetylcholine Receptors as Targetsfor Tobacco Cessation Therapeutics: Cutting-edge Methodologies to Understand Receptor Assembly andTrafficking.- Spectral Confocal Imaging to Examine Upregulation ofNicotinic Receptor Subunits in 4-Yellow Fluorescent Protein Knock-in Mice.- 7-nicotinicAcetylcholine Receptors: New Therapeutic Avenues in Alzheimer's Disease.- 7-nicotinic Acetylcholine Receptors and beta-amyloid Peptides in Alzheimer'sDisease.- Developmentof Antidepressant Drugs Through Targeting a4beta2-Nicotinic AcetylcholineReceptors.- Evolutionary Relationship of Nicotinic Acetylcholine Receptor Subunitsin Both Vertebrate and Invertebrate Species.
Summary
This volume provides properties, biological function, methods,
and approaches for manipulating nAChRs in different organisms. Nicotinic
Acetylcholine Receptor Technologies guides readers through molecular
techniques and behavioral tests used to investigate nicotinic drugs,
chronoamperometry, emerging technologies and methods for the analysis of
nAChRs, single nucleotide polymorphism (SNP), fluorescence techniques, spectral
confocal, allosteric modulators of a7-nAChRs, and a comprehensive evolutional
relation for most nAChR subunits, in both vertebrate and invertebrate species.
Written for the popular Neuromethods series, chapters include the
kind of detail and key implementation advice that ensures successful results in
the laboratory.
Authoritative and practical, Nicotinic Acetylcholine
Receptor Technologies aims to ensure successful results in the
further study of this vital field.
