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Klappentext Gain a foundational understanding of complex physiology concepts with this thoroughly revised text. Cellular Physiology and Neurophysiology, a volume in the Mosby Physiology Series, explains the fundamentals of these multi-faceted areas in a clear and concise manner. It helps bridge the gap between basic biochemistry, molecular and cell biology, and neuroscience, and organ and systems physiology, providing the rich, clinically oriented coverage needed to master the latest concepts in neuroscience and how cells function in health and disease. Inhaltsverzeichnis SECTION I, Fundamental Physicochemical Concepts CHAPTER 1, INTRODUCTION: HOMEOSTASIS AND CELLULAR PHYSIOLOGY Homeostasis Enables the Body to Survive in Diverse Environments The Body Is an Ensemble of Functionally and Spatially Distinct Compartments Transport Processes Are Essential to Physiological Function Cellular Physiology Focuses on Membrane-Mediated Processes and on Muscle Function Summary Key Words and Concepts CHAPTER 2, DIFFUSION AND PERMEABILITY Diffusion Is the Migration of Molecules down a Concentration Gradient Fick's First Law of Diffusion Summarizes our Intuitive Understanding of Diffusion Essential Aspects of Diffusion Are Revealed by Quantitative Examination of Random, Microscopic Movements of Molecules Fick's First Law Can Be Used to Describe Diffusion across a Membrane Barrier Summary Key Words and Concepts Study Problems CHAPTER 3, OSMOTIC PRESSURE AND WATER MOVEMENT Osmosis Is the Transport of Solvent Driven by a Difference in Solute Concentration Across a Membrane That Is Impermeable to Solute Water Transport during Osmosis Leads to Changes in Volume Osmotic Pressure Drives the Net Transport of Water during Osmosis Osmotic Pressure and Hydrostatic Pressure Are Functionally Equivalent in Their Ability to Drive Water Movement Through a Membrane Only Impermeant Solutes Can Have Permanent Osmotic Effects Summary Key Words and Concepts Study Problems CHAPTER 4, ELECTRICAL CONSEQUENCES OF IONIC GRADIENTS Ions Are Typically Present at Different Concentrations on Opposite Sides of a Biomembrane Selective Ionic Permeability Through Membranes Has Electrical Consequences: The Nernst Equation The Stable Resting Membrane Potential in a Living Cell Is Established by Balancing Multiple Ionic Fluxes The Cell Can Change Its Membrane Potential by Selectively Changing Membrane Permeability to Certain Ions The Donnan Effect Is an Osmotic Threat to Living Cells Summary Key Words and Concepts Study Problems SECTION II, Ion Channels and Excitable Membranes CHAPTER 5, ION CHANNELS Ion Channels Are Critical Determinants of the Electrical Behavior of Membranes Distinct Types of Ion Channels Have Several Common Properties Ion Channels Share Structural Similarities and Can Be Grouped into Gene Families Summary Key Words and Concepts Study Problems CHAPTER 6, PASSIVE ELECTRICAL PROPERTIES OF MEMBRANES The Time Course and Spread of Membrane Potential Changes Are Predicted by the Passive Electrical Properties of the Membrane The Equivalent Circuit of a Membrane Has a Resistor in Parallel with a Capacitor Passive Membrane Properties Produce Linear Current-Voltage Relationships Membrane Capacitance Affects the Time Course of Voltage Changes Membrane and Axoplasmic Resistances Affect the Passive Spread of Subthreshold Electrical Signals Summary Key Words and Concepts Study Problems CHAPTER 7, GENERATION AND PROPAGATION OF THE ACTION POTENTIAL The Action Potential Is a Rapid and Transient Depolarization of the Membrane Potential i...
List of contents
SECTION I, Fundamental Physicochemical Concepts
CHAPTER 1, INTRODUCTION: HOMEOSTASIS AND CELLULAR PHYSIOLOGY
Homeostasis Enables the Body to Survive in Diverse Environments
The Body Is an Ensemble of Functionally and Spatially Distinct Compartments
Transport Processes Are Essential to Physiological Function
Cellular Physiology Focuses on Membrane-Mediated Processes and on Muscle Function
Summary
Key Words and Concepts
CHAPTER 2, DIFFUSION AND PERMEABILITY
Diffusion Is the Migration of Molecules down a Concentration Gradient
Fick's First Law of Diffusion Summarizes our Intuitive Understanding of Diffusion
Essential Aspects of Diffusion Are Revealed by Quantitative Examination of Random, Microscopic Movements of Molecules
Fick's First Law Can Be Used to Describe Diffusion across a Membrane Barrier
Summary
Key Words and Concepts
Study Problems
CHAPTER 3, OSMOTIC PRESSURE AND WATER MOVEMENT
Osmosis Is the Transport of Solvent Driven by a Difference in Solute Concentration Across a Membrane That Is Impermeable to Solute
Water Transport during Osmosis Leads to Changes in Volume
Osmotic Pressure Drives the Net Transport of Water during Osmosis
Osmotic Pressure and Hydrostatic Pressure Are Functionally Equivalent in Their Ability to Drive Water Movement Through a Membrane
Only Impermeant Solutes Can Have Permanent Osmotic Effects
Summary
Key Words and Concepts
Study Problems
CHAPTER 4, ELECTRICAL CONSEQUENCES OF IONIC GRADIENTS
Ions Are Typically Present at Different Concentrations on Opposite Sides of a Biomembrane
Selective Ionic Permeability Through Membranes Has Electrical Consequences: The Nernst Equation
The Stable Resting Membrane Potential in a Living Cell Is Established by Balancing Multiple Ionic Fluxes
The Cell Can Change Its Membrane Potential by Selectively Changing Membrane Permeability to Certain Ions
The Donnan Effect Is an Osmotic Threat to Living Cells
Summary
Key Words and Concepts
Study Problems
SECTION II, Ion Channels and Excitable Membranes
CHAPTER 5, ION CHANNELS
Ion Channels Are Critical Determinants of the Electrical Behavior of Membranes
Distinct Types of Ion Channels Have Several Common Properties
Ion Channels Share Structural Similarities and Can Be Grouped into Gene Families
Summary
Key Words and Concepts
Study Problems
CHAPTER 6, PASSIVE ELECTRICAL PROPERTIES OF MEMBRANES
The Time Course and Spread of Membrane Potential Changes Are Predicted by the Passive Electrical Properties of the Membrane
The Equivalent Circuit of a Membrane Has a Resistor in Parallel with a Capacitor
Passive Membrane Properties Produce Linear Current-Voltage Relationships
Membrane Capacitance Affects the Time Course of Voltage Changes
Membrane and Axoplasmic Resistances Affect the Passive Spread of Subthreshold Electrical Signals
Summary
Key Words and Concepts
Study Problems
CHAPTER 7, GENERATION AND PROPAGATION OF THE ACTION POTENTIAL
The Action Potential Is a Rapid and Transient Depolarization of the Membrane Potential in Electrically Excitable Cells
Ion Channel Function Is Studied with a Voltage Clamp
Individual Ion Channels Have Two Conductance Levels
Na_ Channels Inactivate during Maintained Depolarization
Action Potentials Are Generated by Voltage-Gated Na_ and K_ Channels
Action Potential Propagation Occurs as a Result of Local Circuit Currents
Summary
Key Words and Concepts
Study Problems
CHAPTER 8, ION CHANNEL DIVERSITY
Various Types of Ion Channels Help to Regulate Cellular Processes
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