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Informationen zum Autor HONGHUI ZHOU, PHD, FCP, FAAPS, is a Senior Director and Janssen Fellow as well as US Head of Pharmacometrics at Janssen Research & Development, LLC. DIANE R. MOULD, PHD, FCP, FAAPS, is President of Projections Research Inc., a consulting company offering pharmacokinetic and pharmacometric services, and the founder of Baysient LLC, a company that develops systems to individualize doses of drugs that are difficult to manage. Klappentext Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane R. Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis, and lupus Zhou and Mould's timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders. Inhaltsverzeichnis List of Contributors xvii About the Editors xxi Foreword xxiii Preface xxvii 1 Disease Interception in Autoimmune Diseases: From a Conceptual Framework to Practical Implementation 1 Anish Suri 1.1 Introduction to Disease Interception 1 1.2 Disease Interception in Autoimmune Diseases 3 1.3 Progress in Modulation of the Adaptive Immune Response in Autoimmune Inflammatory Diseases 5 1.4 The Complex Interplay between the Specificity of the Pathogenic Immune Repertoire and Its Sculpting by the Environment - Implications for Disease Interception 8 1.5 Clinical Application and Concluding Remarks 14 Acknowledgments 15 References 15 2 The Role of Biomarkers in Treatment Algorithms for Ulcerative Colitis (UC) 25 Reena Khanna and Brian G. Feagan 2.1 Background 25 2.2 Histology 32 2.2.1 Tissue Markers 33 2.3 Treatment Algorithms 34 2.3.1 Differentiating Inflammatory and Noninflammatory Disease 34 2.4 Assessing Response to Therapy 35 2.5 Predicting Relapse 35 2.6 Summary 35 References 35...
