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Informationen zum Autor Peter Curtis-Prior is the editor of The Eicosanoids, published by Wiley. Klappentext This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide.This book satisfies a surge of interest in prostaglandins--NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs). Zusammenfassung Covers such topics as prostaglandin synthetase enzyme, synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. Inhaltsverzeichnis List of Contributors. Preface. Preface from Prostaglandins. Acknowledgements. Foreword. Section One: Biosynthesis and Metabolism 1. Perspectives on the Biosynthesis and Metabolism of Eicosanoids (Robert C. Murphy, Rebecca C. Bowers, Jennifer Dickinson and Karin Zemski-Berry). 2. Control of Eicosanoid Production by Cellular and Secreted Phospholipase A2 (Marise Andreani, Jean-Luc Olivier and Gilbert Béréziat). 3. Mechanisms of PGH synthase-1 (COX-1) activity and role of radical states (Carol Deby and Ginette Deby-Dupont ). 4. Regulation and Function of Prostaglandin Synthase 2/Cyclooxygenase II (Harvey R. Herschman). 5. Mammalian Lipoxygenases (Shozo Yamamoto, Hiroshi Suzuki, Natsuo Ueda, Yoshitaka Takahashi and Tanihiro Yoshimoto). 6. Biosynthesis and Biological Effects of 5-oxo-ETE and other Oxoeicosatetraenoic Acids (William S. Powell). 7. Synthetic Eicosanoids (Norrie. H. Wilson). Section Two: Analytic al Methods 8. Perspectives of Analytical Methods for Eicosanoids (Jay Y. Westcott and Angelo Sala). 9. Enzyme Immunoassays of Metabolites and Enzymes Using Acetylcholinesterase as label (Christophe Créminon and Jacques Maclouf). 10.Bioassay of Eicosanoids (Robert L. Jones). 11. Gas Chromatography and Mass Spectometry in Eicosanoid Analysis (Michinao Mizugaki, Takanori Hishinuma, Naoto Suzuki). 12. Time-resolved Fluoroimmunoassay in Eicosanoid Analysis (Werner Schlegel and Harald John). Section Three: Biochemical and Molecular Pharmacology 13. Perspectives and Clinical Significance of the Biochemical and Molecular Pharmacology of Eicosanoids (Subhash P. Khanapure and L. Gordon Letts). 14. Eicosanoid Antagonists (Kiyoshi Yasui and Akinori Arimura). 15. Biosynthesis and Degredation of Anandamide, an Endogenous Ligand of Cannabinoid Receptors (Natsuo Ueda and Dale G. Deutsch). 16. Inhibitors of Eicosanoids (K. D. Rainsford). 17. Biology and Chemistry of Products of the Isoprostane Pathway (L. Jackson Roberts, II, and Jason D. Morrow). 18. Insight into Prostanoid Functions; lessons from receptor-knockout mice (Yukihiko Sugimoto, Shuh Narumiya and Atsushi Ichikawa). Section Four: Immunology, Endocrinology and Metabolic Regulation 19. Perspectives and Clinical Significance of Eicosanoids in Immunology, Endocrinology and Metabolic Regulation (Milan R. Henzl). 20. Prostaglandins and the Immune Response (Diana C. Fleming and Rodney W. Kelly). 21. Leukotrienes in Aspirin-intolerant Asthma (Anthony P. Sampson and Stephen T. Holgate). 22. Essential Fatty Acids (Yoeju Min and Michael A. Crawford). 23. Endothelial Secretor...
