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This practical volume examines a number of topicsthat explore the current status of immunotherapy and diagnostic markers forneurodegenerative disorders. With a focus on Alzheimer's disease, the firstsections of the book examine immunotherapeutic approaches for theaforementioned disease as well as for Parkinson's disease and Huntington's disease,amongst others. The last section of the book covers the importance of biomarkertechniques to catch these diseases early enough for the treatments to be mostuseful. Written for the Methods inPharmacology and Toxicology series, this book contains the kind of detaileddescriptions and implementation advice that will offer a smooth transition intothe lab.
Authoritative and useful, Immunotherapy and Biomarkers inNeurodegenerative Disorders aims to aid in the continued progress in thedevelopment of novel immune-based drugs and diagnostic tools for thesedevastating brain diseases.
List of contents
Immunotherapy Against Amyloid-beta in Alzheimer's Disease: AnOverview.- Active Immunization Against the Amyloid-beta Peptide.- ImmunotherapyAgainst N-Truncated Amyloid-beta Oligomers.- Immunotherapy Against Amyloid-betaProtofibrils: Opportunities and Challenges.- Immunotherapy Against -SynucleinPathology.- Extracellular -Synuclein as a Target for Immunotherapy.- Immunotherapyof Parkinson's Disease.- TauImmunotherapy.- Active and Passive Immunotherapy Against Tau: Effectsand Potential Mechanisms.- Immunotherapy on Experimental Models forHuntington's Disease.- Cerebrospinal Fluid Biomarkers in Alzheimer's Disease.- VolumetricMRI as a Diagnostic Tool in Alzheimer's Disease.- PET Imaging as a DiagnosticTool in Alzheimer´s Disease.- lpha-Synuclein as a Diagnostic Biomarker forParkinson's Disease.- Imaging as a Diagnostic Tool in Parkinson's Disease.- MassSpectrometry-Based Proteomics in Biomarker Discovery for NeurodegenerativeDiseases.
Summary
With a focus on Alzheimer’s disease, the firstsections of the book examine immunotherapeutic approaches for theaforementioned disease as well as for Parkinson’s disease and Huntington’s disease,amongst others.
