Cybernetic Modeling for Bioreaction Engineering

Describes dynamic state of metabolic systems, while paving the way for fully predictive modeling frameworks.

List of contents

1. Introduction; 2. Enzymatic adaptation; 3. Early development of cybernetic models; 4. Revisiting cybernetic laws via optimal control theory; 5. Towards modeling of metabolic networks; 6. The hybrid cybernetic model (HCM); 7. The lumped hybrid cybernetic model (L-HCM); 8. Predicting dynamic behavior of mutant strains with L-HCM; 9. Nonlinear analysis of cybernetic models; 10. Metabolic modeling landscape; References; Index.

About the author

Doraiswami Ramkrishna is the Harry Creighton Peffer Distinguished Professor of Chemical Engineering at Purdue University, Indiana. He pioneered the development of dynamic metabolic modeling, and has been active in the area for over thirty years. He is a member of the National Academy of Engineering, coined the term 'cybernetic modeling', and has authored several academic books.Hyun-Seob Song is a Senior Research Scientist at Pacific Northwest National Laboratory, Washington (PNNL). His new development of metabolic pathway analysis enabled dynamic metabolic modeling for complex, large-scale networks. He is also active in the areas of network inference and microbial community modeling.

Summary

Offers dynamic models of varying detail, serving a spectrum of needs, ranging from optimization and control of bioprocesses to detailed treatment of metabolism for rational design of new strains.

Product details

• Authors: Doraiswami Ramkrishna, Doraiswami (Purdue University Ramkrishna, Ramkrishna Doraiswami, Hyun-Seob Song, Hyun-Seob (Pacific Northwest National Laboratory Song, Hyun-Seob (Purdue University Song
• Publisher: Cambridge University Press ELT
• Languages: English
• Product format: Hardback
• Released: 31.10.2018
• EAN: 9781107000520
• ISBN: 978-1-107-00052-0
• No. of pages: 294
• Series: Cambridge Series in Chemical Engineering; Cambridge Series in Chemical E; Cambridge Series in Chemical Engineering; Cambridge Series in Chemical E; Cambridge Chemical Engineering
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; TECHNOLOGY & ENGINEERING / Chemical & Biochemical, Chemical Engineering, Biomedical engineering, Biochemical Engineering, Industrial chemistry and chemical engineering