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Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders.
Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies.
List of contents
Section I: Introduction
1. Epigenetics in Human Disease
Section II: Methodology
2. Methods and Strategies to Determine Epigenetic Variation in Human Disease
3. Age Estimates Using DNA Methylation Patterns
4.Bioinformatics of Epigenetic Data Generated from Next-generation Sequencing
Section III: Human Cancer
5. DNA Methylation Alterations in Human Cancers
6. Alterations of Histone Modifications in Cancer
7. MicroRNA in Cancer
8. Epigenetic Approaches to Cancer Therapy
Section lV: Neurological Disease
9. Epigenomics in Neurobehavioral Disease
10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders
11. The Epigenetics of Alzheimer's and Other Neurodegenerative Disease
12. Epigenetic Modulation of Human Neurobiological Disorder
Section V: Autoimmune Disease
13. Epigenetic Basis of Autoimmune Disorders in Humans
14. Approaches to Autoimmune Diseases Using Epigenetic Therapy
Section VI: Metabolic Disorders
15. Epigenomic Factors in Human Obesity
16. Epigenetic Approaches to Control Obesity
17. Epigenetics of Diabetes in Humans
18. The Potential of Epigenetic Compounds in Treating Diabetes
Section VII: Other Disorders/Diseases
19. Epigenetic Aberrations in Human Allergic Diseases
20. Therapy of Airway Disease: Epigenetic Potential
21. The Role of Epigenetics in Cardiovascular Disease
22. Epigenetic Treatment Approaches to Cardiovascular Disease
23. Epigenetics and Human Infectious Diseases
24. Therapy of Infectious Diseases Using Epigenetic Approaches
25. The Epigenetics of Endometriosis
26. Epigenetic DNA Methylation in Endometrial Cancer
27. Epigenetic Treatment Prospects of Gynecological and Reproductive Diseases
Section VIII: Development, Aging and Transgenerational Effects
28. Epigenetics of Transgenerational Inheritance in Disease
29. Epigenetic Mechanisms of Human Imprinting Disorders
30. Therapeutic Approaches to Imprinting Diseases
31. Stem Cell Epigenetics and Human Disease
32. Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy
33. Aging and Disease: The Epigenetic Bridge
34. Epigenetic Programming of Human Disease and Aging
Section lV: Future Research
35. Future Directions in the Epigenetics of Human Disease
About the author
Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
