Coordinating Organismal Physiology Through the Unfolded Protein Response

This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike.

List of contents

Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.- Cell Non-Autonomous UPR^ER Signaling.- The unfolded protein response in the immune cell development: Putting the caretaker in the driving seat.- Mitochondria associated membranes and ER stress.- Coordinating Organismal Metabolism during Protein Misfolding in the ER Through the Unfolded Protein Response.- ER stress and neurodegenerative disease: a cause or effect relationship?- Driving cancer tumorigenesis and metastasis through UPR signaling.- ER Protein Quality Control and the Unfolded Protein Response in the Heart.

About the author

R. Luke Wiseman

Associate Professor
Department of Molecular Medicine
The Scripps Research Institute MEM 220
La Jolla, CA 92037, USA

Phone: [phone]

Email: [e-mail]

Cole M. Haynes
Associate Professor
University of Massachusetts Medical School
Worcester, MA 01605, USA
Email:[e-mail]

Summary

This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike.

Product details

• Assisted by: Cole M. Haynes (Editor), Luke Wiseman (Editor), R Luke Wiseman (Editor), M Haynes (Editor), M Haynes (Editor), R. Luke Wiseman (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2018
• EAN: 9783319785295
• ISBN: 978-3-31-978529-5
• No. of pages: 213
• Dimensions: 157 mm x 242 mm x 19 mm
• Weight: 500 g
• Illustrations: VII, 213 p.
• Series: Current Topics in Microbiology and Immunology; Current Topics in Microbiology and Immunology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Physiologie, Onkologie, B, Neurowissenschaften, Krankheiten und Störungen, Immunology, HUMAN PHYSIOLOGY, PHYSIOLOGY, INTERNAL MEDICINE, Neuroscience, Oncology, Infectious & contagious diseases, Neurosciences, infectious diseases, Biomedical and Life Sciences, Cancer Research, Biomedical Research, Diseases and disorders