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Through the integration of bioinformatic, genetic, transcriptomic, proteomic, metabolomic, phenomic and other massive datasets, genomics is revealing exciting new insights into fungal cell biology. The central theme of this volume is the strong impact that genomics is having upon our understanding of fungal biology, across a wide range of species, including model yeasts (such as Saccharomyces cerevisiae and Schizosaccharomyces pombe ), filamentous fungi (such as Neurospora crassa and Aspergillus nidulans) and pathogenic fungi (such as Magnaporthe grisae, Candida albicans, Cryptococcus neoformans and Histoplasma capsulatum ). World-renowned scientists address the following topics in these fungi: systems biology and evolution, circadian rhythms, apoptosis and stress responses, secretion, and environmental signalling networks. Particular emphasis is placed on fungal pathogenicity. Various genomic technologies are discussed, including genome-wide sequence comparisons, transcript profiling, proteomics, metabolomics and bioinformatics.
List of contents
Fungal Systems Biology and Evolution
1 Metabolomics and Systems Biology in Saccharomyces cerevisiae
J.I. Castrillo and S.G. Oliver
2 Genome Evolution in Hemiascomycete Yeasts
L.J. Montcalm and K.H. Wolfe
3 Investigating the Evolution of Fungal Virulence by Functional Genomics
S. Ahmad, D.M. Soanes, M.C. Barooah and N.J. Talbot
Fungal Rhythms and Responses
4 Circadian Rhythms, Photobiology and Functional Genomics in Neurospora
J.J. Loros and J.C. Dunlap
5 Genomics of Protein Secretion and Hyphal Growth in Aspergillus
D.B. Archer and G. Turner
6 The Genomics of Stress Response in Fission Yeast
B.T. Wilhelm and J. Bähler
7 Programmed Cell Death and Apoptosis in Fungi
M. Ramsdale
8 Genomic Analysis of Cellular Morphology in Candida albicans
M. Whiteway and A. Nantel
Fungal Pathogenicity
9 Postgenomic Approaches to Analyse Candida albicans Pathogenicity
C.A. Munro, C. Fradin, O. Bader and B. Hube
10 Integration of Metabolism with Virulence in Candida albicans
A.J.P. Brown
11 Regulators of Candida glabrata Pathogenicity
K. Haynes
12 Using Genomics to Study the Life Cycle of Histoplasma capsulatum
A. Sil
13 Cryptococcus neoformans Pathogenicity
R.T Nelson and J.K. Lodge
Biosystematic Index
Subject Index
