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Informationen zum Autor Margaret M. Faul received her B.Sc. and M.Sc degrees from University College Dublin, Ireland. She then moved to the US where she received her Ph.D. degree in synthetic organic chemistry from Harvard University with Professor David A. Evans. In 1993 Margaret joined the Chemical Process group at Eli Lilly and Company, and in 2003 she moved to Amgen where she is currently the Executive Director in the Process Development organization. At Amgen, Margaret is responsible for the commercial process development and process characterization of all molecules in both the synthetic and biologic Amgen portfolio. Klappentext The current volume continues the tradition of the Organic Syntheses series, providing carefully checked and edited experimental procedures that describe important synthetic methods, transformations, reagents, and synthetic building blocks or intermediates with demonstrated utility in organic synthesis. These significant and interesting procedures should prove worthwhile to many synthetic chemists working in increasingly diverse areas. A trusted guide for professionals in organic and medicinal chemistry in academia, government, and industries, including pharmaceuticals, fine chemicals, agrochemicals, and biotechnological products. Inhaltsverzeichnis Preparation of Aryl Alkyl Ketenes 1 Nicholas D. Staudaher, Joseph Lovelace, Michael P. Johnson, and Janis Louie Preparation of Diisopropylammonium Bis(catecholato)cyclohexylsilicate 16 Kingson Lin, Christopher B. Kelly, Matthieu Jouffroy, and Gary A.Molander Continuous Flow Hydration of Pyrazine-2-carbonitrile in a Manganese Dioxide Column Reactor 34 Claudio Battilocchio, Shing-Hing Lau, Joel M. Hawkins, and Steven V. Ley Site-Selective C-H Fluorination of Pyridines and Diazines with AgF2 46 Patrick S. Fier and John F. Hartwig Site-Selective C-H Fluorination of Pyridines and Diazines with AgF2 46 Patrick S. Fier and John F. Hartwig Ugi Multicomponent Reaction 54 André Boltjes, Haixia Liu, Haiping Liu, and Alexander Dömling Palladium-catalyzed External-CO-Free Reductive Carbonylation of Bromoarenes 66 Hideyuki Konishi, Masataka Fukuda, Tsuyoshi Ueda, and Kei Manabe Practical Syntheses of [2,2¿-bipyridine] bis [3,5-difluoro-2- [5-(trifluoromethyl)-2 pyridinyl]phenyl]iridium(III) hexafluorophosphate, [Ir{dF(CF3)ppy}2(bpy)]PF6 and [4,4¿- bis (tert-butyl) 2,2¿-bipyridine] bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl]phenyl]iridium(III) hexafluorophosphate, [Ir{dF(CF3)ppy}2 (dbbpy)]PF6 77 Martins S. Oderinde and Jeffrey W. Johannes (Z)-Enol p -Tosylate Derived from Methyl Acetoacetate: A Useful Cross-coupling Partner for the Synthesis of Methyl ( Z )-3-Phenyl (or Aryl)-2-butenoate 93 Yuichiro Ashida, Hidefumi Nakatsuji, and Yoo Tanabe Synthesis of Allenyl Mesylate by a Johnson-Claisen Rearrangement. Preparation of 3-(((tert-butyldiphenyl- silyl)oxy)methyl)penta-3,4-dien-1-yl methanesulfonate 109 Joseph E. Burchick. Jr., Sarah M. Wells, and Kay M. Brummond Rhodium(I)-catalyzed Allenic Pauson-Khand Reaction 123 Joseph E. Burchick. Jr., Sarah M. Wells, and Kay M. Brummond Dirhodium (II) tetrakis[N-4-bromo-1,8-naphthoyl-(S)- tert -leucinate] 136 Hélène Lebel, Henri Piras, and Johan Bartholoméüs Buta-2,3-dien-1-ol 153 Hongwen Luo, Dengke Ma, and Shengming Ma Fragment Coupling and Formation of Quaternary Carbons by Visible-Light Photoredox Catalyzed Reaction of tert -Alkyl Hemioxalate Salts and Michael Acceptors 167 Christopher R. Jamison, Yuriy Slutskyy, and Larry E. Overman N- Methoxy -N- methylcyanoformamide 184 ...
