Sherlock's Diseases of the Liver and Biliary System - 13th edition

A new, fully updated edition of the world's most famous book on liver diseases--with updating of all areas and inclusion of new specific topics, by internationally renowned specialists
 
This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world's leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors' experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category.
 
Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fibrogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fibrosis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website.
* Internationally recognized and loved, world-renowned hepatology book, first published in 1955
* Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock's clarity and legacy of presentation
* Full colour throughout with 700 illustrative figures
* Wide faculty of international contributors
 
Sherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses.

List of contents

List of Contributors xi
 
Preface to the Thirteenth Edition xv
 
Preface to the First Edition xvi
 
1. Anatomy and Function 1
Jay H. Lefkowitch
 
Development of the liver and bile ducts 1
 
Anatomy of the liver 1
 
Functional liver anatomy: sectors and segments 3
 
Anatomical abnormalities of the liver 3
 
Anatomy of the biliary tract 4
 
Surface marking 5
 
Methods of examination 6
 
Microanatomy of the liver 7
 
Hepatic ultrastructure (electron microscopy) and organelle functions 9
 
Functional heterogeneity of the liver 13
 
Dynamics of the hepatic microenvironment in physiology and disease 14 Hepatocyte death and regeneration 15 References 16
 
2 Liver Function in Health and Disease: Clinical Application of Liver Tests 20
George Mells and Graeme Alexander
 
Bilirubin metabolism 21
 
Bile acids 23
 
Lipid and lipoprotein metabolism 26
 
Amino acid metabolism 28
 
Plasma proteins 29
 
Carbohydrate metabolism 31
 
Markers of hepatocellular injury: the serum transaminases 32
 
Markers of cholestasis: alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) 33
 
Haematology in liver disease 34
 
Effects of ageing on the liver 35
 
References 36
 
3 Biopsy of the Liver 39
David Patch and Tu Vinh Luong
 
Selection and preparation of the patient 39
 
Techniques 40
 
Risks and complications 43
 
Sampling variability 45
 
Naked-eye appearances 46
 
Preparation of the specimen 46
 
Interpretation: a stepwise diagnostic approach 46
 
Indications 48
 
Special methods 49
 
References 50
 
4 Coagulation in Cirrhosis 53
Nicolas M. Intagliata and Stephen H. Caldwell
 
Introduction 53
 
Normal coagulation pathways: a hepatologist's perspective 54
 
The coagulation system in cirrhosis 56
 
Bleeding and thrombosis in cirrhosis 57
 
Clinical laboratory tests of the coagulation system in cirrhosis 58
 
Conclusion 60
 
References 60
 
5 Acute Liver Failure 62
Shannan R. Tujios and William M. Lee
 
Definition 62
 
Epidemiology and aetiologies 63
 
Clinical features 66
 
Initial investigations 67
 
Complications and management of acute liver failure 68
 
Specific therapies 73
 
Prognosis 75
 
Liver transplantation 76
 
Conclusion 78
 
References 78
 
6 Hepatic Fibrogenesis 82
Meena B. Bansal and Scott L. Friedman
 
Introduction 82
 
Natural history of hepatic fibrosis 82
 
Cellular and molecular features of hepatic fibrosis 83
 
Clinical aspects of hepatic fibrosis 89
 
Emerging antifibrotic targets and strategies 89
 
References 90
 
7 Non-invasive Assessment of Fibrosis and Cirrhosis 93
Avik Majumdar and Massimo Pinzani
 
Introduction 93
 
The use of invasive and non-invasive tests 93
 
Non-invasive tests: specifics 95
 
Conclusions 102
 
References 103
 
8 Hepatic Cirrhosis 107
P. Aiden McCormick and Rajiv Jalan
 
Definition 107
 
Causes of cirrhosis 107
 
Anatomical diagnosis 108
 
Reversible cirrhosis 110
 
Clinical cirrhosis: compensated versus
 
decompensated 110
 
Prognosis (Child-Pugh score, MELD, UKELD) 111
 
Clinical and pathological associations 112
 
Management 119
 
Acute-on-chronic liver failure 120
 
References 123
 

About the author

James S. Dooley, The Royal Free Hospital, London, UK.
Anna S. Lok, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Guadalupe Garcia-Tsao, Yale University School of Medicine, VA-CT Healthcare System, CT, USA.
Massimo Pinzani, UCL Institute for Liver and Digestive Health, London, UK.

Summary

A new, fully updated edition of the world's most famous book on liver diseases--with updating of all areas and inclusion of new specific topics, by internationally renowned specialists

This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world's leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors' experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category.

Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fibrogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fibrosis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website.
* Internationally recognized and loved, world-renowned hepatology book, first published in 1955
* Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock's clarity and legacy of presentation
* Full colour throughout with 700 illustrative figures
* Wide faculty of international contributors

Sherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses.

Product details

• Authors: James Dooley, James S Dooley, James S. Dooley, James S. Lok Dooley, Gu Garcia-Tsao, Guadalu Garcia-Tsao, Guadalupe Garcia-Tsao, Anna S Lok, Anna S F Lok, Anna S. Lok, Anna S. F. Lok, Massimo Pinzani
• Assisted by: James S. Dooley (Editor), Dooley James S. (Editor), Guadalupe Garcia-Tsao (Editor), Guadalupe Garcia-Tsao et al (Editor), Garcia-Tsao Guadalupe (Editor), Anna S. Lok (Editor), Anna S. F. Lok (Editor), Massimo Pinzani (Editor), Pinzani Massimo (Editor), Ann S F Lok (Editor), Anna S Lok (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 31.07.2018
• EAN: 9781119237549
• ISBN: 978-1-119-23754-9
• No. of pages: 816
• Dimensions: 223 mm x 285 mm x 36 mm
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; Medizin, Gastroenterologie, Hepatologie, Hepatology, Medical Science, Infectious Disease & Microbiology, Infektionskrankheiten u. Mikrobiologie, Gastroenterologie u. Hepatologie, Gastroenterology & Hepatology