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This vital collection provides a unique set of techniques to explore the clinical, pathological, and research aspects of the management of patients with esophageal adenocarcinoma. Beginning with an introduction to the basic features of esophageal adenocarcinoma, the book continues with clinical protocols for the management of the cancer, pathological methods for management of the patients and research, as well as protocols for molecular research, which could aid researchers in furthering our understanding of pathogenesis as well as in identifying new targets for the treatment and prevention of adenocarcinoma. Written for the highly successful Methods in Molecular Biology series, chapters include introductions on their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and authoritative, Esophageal Adenocarcinoma: Methods andProtocols is a valuable guide to stimulate specialists from various disciplines in their continuing research into esophageal adenocarcinoma and translating that research into improving the management of this cancer of rising importance.
List of contents
Introduction: Esophageal Adenocarcinoma: Updates of Current Status.- Radiotherapy for Esophageal Adenocarcinoma.- Chemotherapy for Esophageal Adenocarcinoma.- Surgical Protocol for Esophageal Adenocarcinoma.- Target Therapy for Esophageal Adenocarcinoma.- Histopathological Assessment for Esophageal Adenocarcinoma.- Macroscopic Assessment and Cut Up of Endoscopic Resection Specimens for Early Esophageal Glandular Malignancies.- Processing of Surgical Specimen (Esophagogastrectomy) for Esophageal Adenocarcinoma.- Application of Pathological Staging in Esophageal Adenocarcinoma.- Application of Tissue Microarray in Esophageal Adenocarcinoma.- Predictive Marker: HER2 in Esophageal Adenocarcinoma.- Whole-Slide Imaging for Esophageal Adenocarcinoma.- Animal Model: Reflux Models in Esophageal Adenocarcinoma.- Animal Model: Xenograft Mouse Models in Esophageal Adenocarcinoma.- Identification of Cancer Stem Cells in Esophageal Adenocarcinoma.- Circulatory Tumor Cells in Esophageal Adenocarcinoma.- Liquid Biopsy for Investigation of Cancer DNA in Esophageal Adenocarcinoma: Cell-Free Plasma DNA and Exosome-Associated DNA.- Somatic DNA Copy Number Alterations Detection for Esophageal Adenocarcinoma Using Digital Polymerase Chain Reaction.- Targeted Single Gene Mutation in Esophageal Adenocarcinoma.- DNA Genome Sequencing in Esophageal Adenocarcinoma.- Epigenetics: DNA Methylation Analysis in Esophageal Adenocarcinoma.- Detection and Quantification of MicroRNAs in Esophageal Adenocarcinoma.- RNA Interference-Mediated Gene Silencing in Esophageal Adenocarcinoma.- Proteomic Protocol in Esophageal Adenocarcinoma.
Summary
This vital collection provides a unique set of techniques to explore the clinical, pathological, and research aspects of the management of patients with esophageal adenocarcinoma. Beginning with an introduction to the basic features of esophageal adenocarcinoma, the book continues with clinical protocols for the management of the cancer, pathological methods for management of the patients and research, as well as protocols for molecular research, which could aid researchers in furthering our understanding of pathogenesis as well as in identifying new targets for the treatment and prevention of adenocarcinoma. Written for the highly successful Methods in Molecular Biology series, chapters include introductions on their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and authoritative, Esophageal Adenocarcinoma: Methods andProtocols is a valuable guide to stimulate specialists from various disciplines in their continuing research into esophageal adenocarcinoma and translating that research into improving the management of this cancer of rising importance.
