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This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.
List of contents
Target Mitochondria.- SECTION I-Mitochondrial Biology.- Introduction: Mitochondria: the cell furnace.- MItochondria: Where are They Coming From?.- Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality.- Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore.- Mitochondrial Regulation of Cell Death.- MItochondria in Liver Diseases.- Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction.- MItochondrial Remodeling in Cancer.- Mitochondria in Kidney Disease.- CNS diseases and disruption of Mitochondria.- Mitochondrial disruption in cardiovascular diseases.- .Drug-inducing Mitochondrial Toxicity.- MItochondrial DNA: Functions and Role in Acquired Diseases.- SECTION II-MItochondrial Therapeutics: From the Bench to Industry and Patient.- The Evolution of Mitochondrial Toxicity Assessment in Industry.- Designing Mitochondrial-Active Molecules: The Road to MitoQ and Beyond.- Recovering Mitochondrial Function in Patients' Fibroblasts.- Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity.- Modulation of Cell Fate by Tauroursodexycholic Acid: All Paths Lead to Mitochondria.- Pharmacological Targeting of the Mitchondrial Permeability Transition Pore.- Strategies to Preserve/Improve Mitochondrial Function in Organ Preservation Solutions.- MItochondrial Targeted Redox Active Compounds and the Astrocytemotoneuron Axis: relevance for the Treatment of Amyotrophic Lateral Sclerosis.- Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of the Mitochondrial Gene Experssion.- Mitochoncrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and other Natural Supplements.- Development of Mitochondrial-Directed Plastoquinones.- Targeted Mitochondrial Genome Editing.- Targeting Therpeutic Nucleic Acids into Mitochondria: A Long Challenge.- Cell Permeable Peptides Targeting Mitochondria.- MItochondrial -Directed Cancer Therapy.- SkQ1: The Road from the Bench to the Market.- MItochondrial Follies: Comic.
About the author
Paulo J. Oliveira is recognized for his work as the Coordinator of the Mitochondrial, Metabolism, and Disease Group at the Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Portugal and is the current Vice-President of the European Society of Clinical Investigation (ESCI). He has previously spent some time at the University of Minnesota Medical School, Duluth, investigating the mitochondrial mechanisms of anthracycline-induced selective cardiotoxicity. Throughout his career, he has been involved in projects in which the objective was to advance fundamental knowledge and methodological aspects of mitochondrial research. His current research interests include the role of mitochondria in cardiovascular and liver diseases, the relationship between mitochondrial remodeling and (cancer) stem cell biology, development of novel mitochondrial-targeted therapeutics, as well as the mechanisms of drug-related mitochondrial toxicity. Dr. Oliveira has co-authored close to 200 publications focusing on mitochondrial research.
Summary
Combines basic research with commercial applications so that the reader can understand the complete process of developing molecules that target mitochondria
Illustrates the role of mitochondria in cell life and cell death in relation to a variety of diseases through the use of illustrative comics in Chapter
Discusses the most current issues and advances in the research of mitochondrial-targeted agents and drug therapy
