Charney & Nestler''s Neurobiology of Mental Illness

In the years following publication of the DSM-5®, the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis.

In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text.

In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit.

Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress.

The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5®, which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

List of contents

• Section 1: Emerging and Established Technologies


• 1. Genetic Methodologies and Applications


• Shaun M. Purcell


• 2. Network Methods for Elucidating the Complexity of Common Human Diseases


• Eric E. Schadt


• 3. The Human Brain and its Epigenome


• Andrew Chess and Schahram Akbarian


• 4. Methods for In Vivo Gene Manipulation


• Lisa M. Monteggia and Wei Xu


• 5. Application of Stem Cells to Understanding Psychiatric Disorders


• Zijia Zhang and Kristen Brennand


• 6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges


• Lief E. Fenno and Karl Deisseroth


• 7. In Vivo Circuit Analysis


• Ryan Bowman, Hannah Schwennsen, Kafui Dzirasa, and Rainbo Hultman


• 8. Magnetic Resonance Methodologies


• Peter A. Bandettini and Hanzhang Lu


• 9. PET Brain Imaging Methodologies


• Ansel T. Hillmer, Kelly P. Cosgrove, and Richard E. Carson


• 10. Neuromodulation and Psychiatric Disorders


• Wayne K. Goodman and Mark S. George


• 11. The Neurobiology of Sleep


• Giulio Tononi and Chiara Cirelli


• Section 2: Psychotic Disorders


• 12. Diagnosis and Epidemiology of Psychotic Disorders


• Emma Meyer, Julie Walsh-Messinger, and Dolores Malaspina


• 13. Genetics of Schizophrenia and Bipolar Disorder


• Pamela Sklar


• 14. Neuroimaging of Psychotic Disorders


• Stephan Heckers, Neil Woodward, and Dost Öngür


• 15. Animal and Cellular Models of Psychotic Disorders


• Mikhail V. Pletnikov, Guo-Li Ming, and Christopher A. Ross


• 16. Cognitive and Motivational Neuroscience of Psychotic Disorders: Animal and Human Studies


• Jared Young, Alan Anticevic, and Deanna M. Barch


• 17. Synaptic Mechanisms of Psychotic Disorders: Animal and Human Studies


• Seth G. N. Grant


• 18. Cellular Mechanisms of Psychotic Disorders: Human Studies


• Samuel J. Dienel and David A. Lewis


• 19. Neurodevelopmental Mechanisms for Psychotic Disorders: Animal and Human Studies


• Nao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, and Akira Sawa


• 20. The Neurobiology and Treatment of Bipolar Disorder


• Katherine E. Burdick, Luz H. Ospina, Stephen J. Haggarty, and Roy H. Perlis


• 21. Novel Approaches for Treating Psychotic Disorders


• Tiago Reis Marques and Shitij Kapur


• 22. Current Treatments for Psychotic Disorders


• Deepak K. Sarpal and Anil K. Malhotra


• Section 3: Depression


• 23. Diagnosis and Epidemiology of Depression


• Nicholas T. Van Dam, Brian M. Iacoviello, and James W. Murrough


• 24. Genetics of Depression


• Douglas F. Levinson and Walter E. Nichols

About the author

Dennis S. Charney, MD
Anne and Joel Ehrenkranz, Dean,
Icahn School of Medicine at Mount Sinai
President for Academic Affairs
Mount Sinai Health System
Professor, Departments of Psychiatry, Neuroscience, and
Pharmacological Sciences
New York, NY

Joseph D. Buxbaum, PhD
G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences
Deputy chair, department of psychiatry
Director, Seaver Autism Center for research and treatment
Icahn School of Medicine at Mount Sinai
New York, NY

Pamela Sklar, MD, PhD
Mount Sinai professor of Psychiatric genomics
Chair, department of Genetics and Genomic Sciences Professor, Departments of Genetics and Genomic Sciences, Psychiatry, Neuroscience, and
Director, Center for Psychiatric Genomics
Icahn School of Medicine at Mount Sinai
New York, NY

Eric J. Nestler, MD, PhD
Nash Family Professor
Departments of Neuroscience and Psychiatry
Director, The Friedman Brain Institute
Dean for academic and scientific affairs
Icahn School of Medicine at Mount Sinai
New York, NY

Summary

In the years following publication of the DSM-5®, the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis.

In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text.

In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit.

Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress.

The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5®, which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Product details

• Authors: Dennis S. Charney, Dennis S. (Anne and Joel Ehrenkranz Dean Charney
• Assisted by: Joseph D. Buxbaum (Editor), Joseph D. (Professor of Psychiatry Buxbaum (Editor), Buxbaum Joseph D. (Editor), Dennis S. Charney (Editor), Dennis S. (Anne and Joel Ehrenkranz Dean Charney (Editor), Charney Dennis S. (Editor), Eric J. Nestler (Editor), Eric J. (Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute Nestler (Editor), Nestler Eric J. (Editor), Pamela Sklar (Editor), Pamela (Chief of the Division of Psychiatric Genomics; Professor of Psychiatry Sklar (Editor), Sklar Pamela (Editor)
• Publisher: Oxford University Press
• Languages: English
• Product format: Hardback
• Released: 31.03.2018
• EAN: 9780190681425
• ISBN: 978-0-19-068142-5
• No. of pages: 1024
• Dimensions: 222 mm x 286 mm x 44 mm
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; MEDICAL / Neurology, Psychiatry, Neurology & clinical neurophysiology, Neurology and clinical neurophysiology