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Hemiplegia and hemiparesis are the most common deficits caused by stroke.A randomized placebo-controlled trial was conducted at Chittagong Medical College Hospital from .One hundred and twenty eight patients, aged between 40-60 years with a diagnosis of acute ischaemic stroke who fulfilled criteria were selected for the study. Eligible patients were randomly assigned, Fluoxetine (20 mg once per day, orally) or placebo group for 3 months starting within 10 days after the onset of stroke. The primary outcome was the mean change in the Rivermead Mobility Index (RMI) score between inclusion (day 0) and day 90. RMI score was significantly changed from D 0 to D 90 in Fluoxetine group in comparison to placebo group (p.001) and mean (±SD) improvement of RMI score in 90 days were significantly greater in the Fluoxetine group, than in the placebo group [7.08(±3.26) vs. 4.40(±2.53)].Patients treated with Fluoxetine were nearly 3.2 times more likely to show motor improvement than placebo group and the NNT was 2. In patients with acute ischaemic stroke and with motor deficit, the early administration of Fluoxetine with physiotherapy enhanced motor recovery after 3 months.
About the author
Dr. Mahfuzur Rahman born on September 1, 1962. After completion M.B.B.S from Sylhet M.A.G. Osmani Medical College he engaged himself to serve humanity as a doctor. He completed M.D. (Doctor of Medicine) from Chittagong Medical College and Hospital. This is his research work. He likes to give thanks to his wife Kaniz, and his two sons Arnab and Ayon.
