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The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors.This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.
List of contents
A Perspective on the Treatment of Acute Lymphoblastic Leukemia.- Clinical Features and Making the Diagnosis.- The Biology of Adult Acute Lymphoblastic Leukemia.- Minimal Residual Disease in Acute Lymphoblastic Leukemia.- Cytogenetics.- Acute Lymphoblastic leukemia: Epidemiology.- Prognostic Factors in Acute Lymphoblastic Leukemia.- The Generalized Care of the Patient with Acute Lymphoblastic Leukemia.- Treatment of Acute Lymphoblastic Leukemia in Middle-Age and Older Adults.-Pharmacology of Acute Lymphoblastic Leukemia Therapy.- Assessment of Response to Treatment.- T-cell Acute Lymphoblastic Leukemia.- Burkitt Leukemia and Lymphoma.- Treatment of Acute Lymphoblastic Leukemia in Young AdultsNicolas Boissel.- Treatment of Philadephia Chromosome Positive Acute Lymphoblastic Leukemia.- Molecular Therapies.- Treatment of Relapsed/ Refractory Acute Lymphoblastic Leukemia.- Allogenic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Adults.- Hematopoietic Stem Cell Transplantation in Philadelphia-positive Acute Lymphoblastic Leukemia.- Special Challenges: Genetic polymorphisms and therapy.- Late Consequences of Therapy of Acute Lymphoblastic Leukemia.- Immunotherapy for Acute Lymphocytic Leukemia.- Unique Subtypes in Acute Lymphoblastic Leukemia.
Summary
The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists.
Additional text
From the reviews:
“The focus of this book is on acute lymphocytic leukemia in adults, with frequent allusions to the childhood form of disease. … the only recent text solely focused on acute lymphocytic leukemia as it relates to subtypes of disease in each of the adult age groups. It is up to date and well referenced, and it integrates basic, translational, and clinical science. As such it serves as a unique resource for scientists and clinicians in the field of acute lymphocytic leukemia.” (Paulette Mehta, Journal of the American Medical Association, June, 2011)
“Twenty-three chapters cover a range of clinically biased topics, from diagnosis and epidemiology to assessment of response to therapy, salvage protocols and the late effects of successful therapy. The text is broken up by tables, graphs and occasional colour illustrations, while extensive lists of references supplement each chapter. … A section on the biology of ALL helps to explain the diversity and underlying genetic instability of the disease. … this collection of reviews will prove to be a very useful supplementary reference text.” (Maria H. Gilleece, Bulletin of the Royal College of Pathologists, April, 2012)
Report
From the reviews:
"The focus of this book is on acute lymphocytic leukemia in adults, with frequent allusions to the childhood form of disease. ... the only recent text solely focused on acute lymphocytic leukemia as it relates to subtypes of disease in each of the adult age groups. It is up to date and well referenced, and it integrates basic, translational, and clinical science. As such it serves as a unique resource for scientists and clinicians in the field of acute lymphocytic leukemia." (Paulette Mehta, Journal of the American Medical Association, June, 2011)
"Twenty-three chapters cover a range of clinically biased topics, from diagnosis and epidemiology to assessment of response to therapy, salvage protocols and the late effects of successful therapy. The text is broken up by tables, graphs and occasional colour illustrations, while extensive lists of references supplement each chapter. ... A section on the biology of ALL helps to explain the diversity and underlying genetic instability of the disease. ... this collection of reviews will prove to be a very useful supplementary reference text." (Maria H. Gilleece, Bulletin of the Royal College of Pathologists, April, 2012)
