Read more
Informationen zum Autor Yvonne Will, PhD, is a Senior Director and the Head of Science and Technology Strategy, Drug Safety Research and Development at Pfizer, Connecticut, USA. In addition to the prior edition of this book, she co-edited Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers (Wiley, 2016). James A. Dykens, PhD, oversees EyeCyte Therapeutics, a start-up developing treatments for progressive blinding diseases via targeting mitochondrial dysfunction. He co-edited the first edition of this book. Klappentext A major public health concern, despite regulatory vigilance, is untoward toxicity and other pharmaceutical side effects. This toxicity is often idiosyncratic, and usually not discovered until after a large population has been exposed and injured. Recent laboratory evaluations show that many of these drugs impact mitochondrial function. The realization that mitochondrial toxicity is a widespread and important issue in drug toxicity is increasingly appreciated, and most pharmaceutical companies now either have the technology to assess this risk themselves, or do so via contract research organizations. Developed as a one-stop reference source for drug safety and toxicology professionals, the second edition of Drug and Environmental Induced Mitochondrial Dysfunction explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. It allows readers to understand the basis of mitochondrial function and the preclinical assessments used and what they reveal about drug effects. The focus is on how the requisite technology continues to evolve and the recent emergence of clinical techniques capable of detecting drug-induced mitochondrial toxicity in patients. Added coverage in the 2nd edition includes how and why mitochondrial toxicity underlies organ injury, clinical reports on drug classes, and discussion of environmental toxicants that can affect mitochondria. With chapters contributed by leading specialists in their areas, Drug and Environmental Induced Mitochondrial Dysfunction , 2nd Edition continues to serve as a valuable resource for safety assessment professionals in the pharmaceutical industry - including bench scientists and managers - and for pharmacologists and toxicologists in both drug and environmental health sciences. Drug and Environmental Induced Mitochondrial Dysfunction provides ample reminders of the intimate connections between mitochondria, pharmacology, and toxicology. The book takes a rather systematic approach to mitochondrial pharmacology and toxicology and, for this reason, will be of use to even those outside of strict drug discovery. Zusammenfassung Developed as a one-stop reference source for drug safety and toxicology professionals! this book explains why mitochondrial failure is a crucial step in drug toxicity and how to avoid it. It allows readers to understand the basis of mitochondrial function and the preclinical assessments used and what they reveal about drug effects. Inhaltsverzeichnis Volume 1 List of Contributors xvii Foreword xxix Part 1 Basic Concepts 1 1 Contributions of Plasma Protein Binding and Membrane Transporters to Drug?]Induced Mitochondrial Toxicity 3 Gavin P. McStay 2 The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity 15 Kathleen M. Giacomini and Huan?]Chieh Chien 3 Structure-Activity Modeling of Mitochondrial Dysfunction 25 Steve Enoch, Claire Mellor, and Mark Nelms 4 Mitochondria?]Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic Induced Toxicity 35 Haider Raza, F. Peter Guengerich, and Narayan G. Avadhani Part 2 Organ Drug Toxicity: Mitochondrial Etiology 47 5 Mitochondrial Dysfunction in Drug?]Induced Liv...
