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This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.
List of contents
Tumor Targeting by RGD-Grafted PLGA-Based Nanotheranostics Loaded with Paclitaxel and Superparamagnetic Iron Oxides.- Fabrication of cRGD Conjugated Dual Responsive Micelles to Target vbeta5 Integrin Overexpressed Cancer.- Copper-Free Click Chemistry Modification of Nanovectors for Integrin Targeted Cancer Therapy.- Preparation, Characterization, and In Vitro and In Vivo Evaluation of PEGylated Liposomal Doxorubicin Modified with Different cRGD Peptides.- Preparation of Heterobivalent and Multivalent Radiopharmarmaceuticals to Target Tumors Over-Expressing Integrins.- 177Lu Labeled RGD-BBN Peptide for Targeting Prostate Cancer.- Integrin-Mediated Targeting of Liposomally-Bound siRNAs to Tumor Vasculatures.- Integrin vbeta3-Targeted Optical Imaging with Metal Oxide Nanomaterials: Focusing on Zinc Oxide.- Integrin Targeting Using RGD-Based Peptide Amphiphiles.- Cyclic-RGDfK-Directed Docetaxel Loaded Nanomicelles for Angiogenic Tumor Targeting.- Targeting Glioma Cancer Cells with Fluorescent Nanodiamonds Via Integrin Receptors.- NIR Imaging-Guided Photothermal Therapy by cRGD-Conjugated Solid Lipid Nanoparticles Encapsulating IR-780.- Synergistic Active Targeting to B16F10 Tumors by vbeta3/CD44-Targeted Nanoparticles Loaded with Docetaxel.
Summary
This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular. The chapters consecutively describe the tools for structural analysis, identification and detection of integrins as biomarkers, and include thorough laboratory and clinically-related methods on different strategies for generation, synthesis and evaluation of probes, carriers, peptides or small particles for integrin targeting, imaging, and drug delivery. As part of the Methods in Pharmacology and Toxicology series, this book contains the practical details that are invaluable in the laboratory.
Authoritative and advantageous, Integrin Targeting Systems for Tumor Diagnosis and Therapy serves readers from a wide spectrum, including researchers and students seeking an overview of existing developments, as well as leading professionals aiming to become more familiar with integrin-related innovative technologies in cancer research.
