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The objective of this study was to investigate the in vitro interactions of lisinopril with metformin using the principle of the dissolution test. The study was conducted using the USP apparatus II paddle method with the temperature set at 37 C body temperature. The media used were buffer pH 1.2, 4.5, and 6.8 to simulate gastrointestinal tract pH. Lisinopril tablets (10 mg strength) were run in the presence of 500 mg metformin tablets and the degree of interaction was established after analyzing the dissolution samples with High-Performance Liquid Chromatography coupled with a ultra-violet detector. The results indicated a statistically significant difference in the effect of lisinopril on the dissolution profile of metformin at pH 1.2, 4.5, and 6.8, with a decrease in the percentage of metformin, released (p = 0.0052; p = 0.0037; and p = 0.0155, respectively). The effect of metformin on the dissolution profile of lisinopril was statistically significant at pH 1.2 and 6.8 with an increase in the percentage of lisinopril released (p = 0.0062; p =0.0036, respectively). However, there was no statistically significant difference at pH 4.5 (p = 0.7174).
About the author
Kosisochi Chinwendu Amorha is a pharmacist and lecturer at the Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka (UNN).
Summary
They were on their own -- three kids and one giant chicken. Stuck in Hoboken for the summer, Nick Itch, Loretta Fischetti, and Bruno Ugg are really, really bored. After whiling away their time spitting in the Hudson River and trying to teach Henrietta, Nick's 266-pound chicken, how to juggle marshmallows, they're ready for something -- anything -- to happen.
When a mysterious and brilliant chalk artist starts decorating Hoboken's streets, the three friends are blown away. They set off to explore the art world in a frenzy of adventurous drawing, screeving, and eggplant picnics.
Additional text
" . a sweetly cock-eyed ode to composition, color and form."
