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Informationen zum Autor His research on chikungunya virus (CHIKV) preceded the ongoing epidemics that have recently infected over 1M people in the Americas. His development of patented infectious clones of this CHIKV placed his group at the forefront of research on this virus. They have distributed these research tools to other groups in an effort to better understand the epidemic. They have published over 30 papers on many aspects of chikungunya with collaborators from multiple institutes in different countries. Dr. Vanlandingham’s research is focused on the interactions between arboviruses, the mosquito vectors, and the vertebrate host. Infectious clone technology is used to identify the molecular determinants of infection of alphaviruses, bunyaviruses, and flaviviruses. There are currently four areas of research in her laboratory: 1) Rift Valley fever virus vaccine development; 2) examining vector competence of North American mosquitoes for Japanese encephalitis virus; 3) rationale vaccine design based on characterizing yellow fever virus to identify molecular determinants of infectivity and transmissibility by Ae. aegypti mosquitoes; and 4) assessing CHIKV-mosquito interactions and virus inactivation procedures to ensure blood transfusion safety. Dana obtained her B.S. and M.S. degrees from Colorado State University and her Ph.D from the Liverpool School of Tropical Medicine in 2006. Klappentext Chikungunya and Zika viruses provides the primary "go-to" source for both historical and current information on these increasingly important human pathogens. Both viruses are newly emerged pathogens that have recently become established in greatly expanded global ranges, to threaten hitherto unexposed populations. Epidemics since 2004 have spread from Africa and Asia to Europe and have caused millions of cases in the Americas. The viruses have probably established themselves in South and Central America permanently leaving millions at risk for future infection. Chikungunya virus (CHIKV) causes severe crippling arthritis and symptoms that can last for months or years. Infections with Zika virus (ZIKV) have been associated with potentially fatal neurological symptoms notably to children of women infected during pregnancy. There are no approved vaccines or specific treatments available. Chikungunya and Zika viruses contributes significantly to our understanding of these pathogens. This dedicated monograph brings this combined knowledge together to provide a single up-to-date source of information.-- Inhaltsverzeichnis 1. History of Chikungunya 2. Transmission Cycle 3. Human Diseases 4. Chikv in Africa 5. Chikv in Asia 6. Chikv in Europe 7. Chikv in Americas 8. Chikv Genetics 9. Diagnostics and Laboratory Techniques 10. Animal Models 11. Vaccine Candidates 12. The Future ...
List of contents
1. History of Chikungunya
2. Transmission Cycle
3. Human Diseases
4. Chikv in Africa
5. Chikv in Asia
6. Chikv in Europe
7. Chikv in Americas
8. Chikv Genetics
9. Diagnostics and Laboratory Techniques
10. Animal Models
11. Vaccine Candidates
12. The Future
Report
"The arguments are well grounded in classical work on evolution, but also on own research in blood cancers, and various observations across cancer research laboratories and clinic." --The Quarterly Review of Biology
