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This volume provides comprehensive information and detailed laboratory protocols used in the study of prion diseases. The chapters in this book cover topics such as: electron microscopy, neuropathology, immunohistochemistry, and immune-gold electron microscopy of prion diseases. Chapters also provide readers with detailed information about kuru, the clinical description of prion diseases, and the detection of prion protein and biomarkers. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and authoritative, Prion Diseases is a valuable resource for researchers and scientists in the exciting and rapidly growing field of prion disease research.
List of contents
Kuru: Introduction to Prion Diseases.- Anthropological Methods used in Kuru Research.- Nonhuman Primates in Research on Transmissible Spongiform Encephalopathies.- Clinical Features and Diagnosis of Human Prion Diseases.- Neuropathology, Immunohistochemistry, and Biochemistry in Human Prion Diseases.- Sub-Cellular and Molecular Changes Associated with Abnormal PrP Accumulation in Brain and Viscera of Classical and Atypical Prion Diseases.- Electron Microscopy of Prion Diseases.- Cell Death and Autophagy in Prion Diseases.- Methods for Isolation of Spiroplasma
sp. from Prion Positive Eye Tissues of Sheep Affected with Terminal Scrapie.- Detection and Diagnosis of Prion Diseases using RT-QuIC: An Update.- Analysis of Charge Isoforms of the Scrapie Prion Protein using Two-Dimensional Electrophoresis.- Exosomes in Prion Diseases.- Synthetic Mammalian Prions.- Biomarkers in Cerebrospinal Fluid.- The Use of Transgenic and Knock Out Mice in Prion Research.- Transgenic Mouse Models of Prion Diseases.
Summary
This volume provides comprehensive information and detailed laboratory protocols used in the study of prion diseases. Chapters also provide readers with detailed information about kuru, the clinical description of prion diseases, and the detection of prion protein and biomarkers.
