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This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamber to measure serum levels of different biomarkers, creating a microfluidic proteomic platform that can easily be translated into a biomarker diagnostic. The Osteokit System, a result of the integration of electrochemical system and microfluidic chips, is a unique design that offers the potential for greater sensitivity. The implementation, feasibility, and specificity of the Osteokit platform is demonstrated in this book, which is appropriate for researchers working on bone biology and mechanics, as well as clinicians.
List of contents
Introduction.- Literature Overview.- Scientific Background.- Conjugated AuNP-antibody Nanoprobe Fabrication and Validation.- Electrochemical Chip Preparation.- Oc and CTX Biosensors: Characteristics and Validation.- Osteokit Fabrication.- Osteokit Validation.- Conclusion and Final Remarks.
About the author
Patricia Khashayar is a biomedical scientist who has published more than 100 academic articles. She received her MD from Tehran University of Medical Sciences in 2006, and an MSc in Medical Education from the same university in 2009. Patricia received a PhD in Nanobiotechnology from University of Tehran and a PhD in Biomedical Engineering from Ghent University, Belgium.Her MSc thesis won the award for Best Educational Process in the 2nd Educational Festival of Shahid Motahri, Iran in 2009. In 2011, she was selected as the International Osteoporosis Foundation (IOF)’s Young Investigator in the Middle East. In the same year she was acknowledged as the Elite Research Student in Razi Festival in Medical Sciences, which is one of the most prestigious awards in Iran.
Summary
This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamber to measure serum levels of different biomarkers, creating a microfluidic proteomic platform that can easily be translated into a biomarker diagnostic. The Osteokit System, a result of the integration of electrochemical system and microfluidic chips, is a unique design that offers the potential for greater sensitivity. The implementation, feasibility, and specificity of the Osteokit platform is demonstrated in this book, which is appropriate for researchers working on bone biology and mechanics, as well as clinicians.
