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Molecular imaging of drugs or drug carriers is a valuable tool that can provide important information on spatiotemporal distribution of drugs, allowing improved drug distribution at target sites. Chemically labelled drugs can be used to both diagnose and treat diseases. This book introduces the topic of image guided drug delivery and covers the latest imaging techniques and developments in theranostics, highlighting the interdisciplinary nature of this field as well as its translational ability. These technologies and techniques hold potential for individualised, safer therapies.
The book introduces the chemistry behind labelling drugs or drug carriers for imaging. It then discusses current scientific progress in the discovery and development of theranostic agents as well as the latest advances in triggered drug delivery. Novel imaging techniques that can be combined with therapeutics are presented, as well as results and findings from early clinical trials.
This text will provide postgraduates and researchers in various disciplines associated with drug discovery, including chemistry, device engineering, oncology, neurology, cardiology, imaging, and nanoscience, an overview of this important field where several disciplines have been combined to improve treatments. Readers will be introduced to techniques that can be translated to the clinic and be applied widely.
List of contents
Image Guided Focused Ultrasound as a New Method of Targeted Drug Delivery; Image-guided Drug Delivery Systems Based on NIR-absorbing Nanocarriers for Photothermalchemotherapy of Cancer; Applications of Magnetic Nanoparticles in Multi-modal Imaging; Photodynamic Therapy; Radiolabelling Liposomal Nanomedicines for PET Imaging; Liposomes for Hyperthermia Triggered Drug Release; Targeted Delivery with Ultrasound Activated Nano-encapsulated Drugs; Theranostics in the Gut; Microwave Imaging and the Potential of Contrast Enhancing Agents for Theranostics Use
About the author
Dr Thanou is a Senior Lecturer in the Institute of Pharmaceutical Science, King's College London and an Honorary Research Fellow at Imperial College London. She finished her PhD in LACDR (Leiden/Amsterdam Centre for Drug Research) in 2000 and after a short period as project manager in Kytogenics Pharmaceuticals Inc., she took her first academic appointment at Cardiff University as Lecturer in Polymer Therapeutics. She continued her career as Dorothy Hodgkin Royal Society Fellow at Imperial College, at the Department of Chemistry and the Genetic Therapies Centre. She is a drug delivery scientist and is currently focusing on the design and development of nanoparticles for Image Guided Drug Delivery. She has published a variety of academic articles on these topics and she is the main or co-inventor of a number of patents.
Summary
This book gives an overview of a field where several disciplines have come together towards individualised, safer therapies, and better monitoring of disease and drug action and distribution.
