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This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine.
-Accessible to biologists looking for new ways to model their results and engineers interested in biomedical applications
-Useful to researchers in biomaterials, inflammation, and vascular biology
-Excellent resource for graduate students as a textbook in cell & tissue engineering or cell mechanics courses This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine.
-Accessible to biologists looking for new ways to model their results and engineers interested in biomedical applications
-Useful to researchers in biomaterials, inflammation, and vascular biology
-Excellent resource for graduate students as a textbook in cell & tissue engineering or cell mechanics courses
List of contents
Partial Contents:
PART I. NEUTROPHIL ADHESION
Adhesion of flowing neutrophils to model vessel surfaces
Bond formation during cell compression
A flow chamber for capillary networks
Membrane dynamics during neutrophil recruitment
Hydrodynamic recruitment of cells to reactive surfaces
PART II: CELL-SUBSTRATE ADHESION
Cell tensegrity models and cell-substrate interactions
Use of hydrodynamic shear stress to analyze cell adhesion
Traction forces exerted by endothelial cells
Control of endothelial cell adhesion by mechanotransmission
PART III. ENGINEERED BIOMIMETIC SURFACES
Realistic atomistic modeling of protein adsorption to ceramic biomaterials
Cell responses to micro- and nano-topography Partial Contents:
PART I. NEUTROPHIL ADHESION
Adhesion of flowing neutrophils to model vessel surfaces
Bond formation during cell compression
A flow chamber for capillary networks
Membrane dynamics during neutrophil recruitment
Hydrodynamic recruitment of cells to reactive surfaces
PART II: CELL-SUBSTRATE ADHESION
Cell tensegrity models and cell-substrate interactions
Use of hydrodynamic shear stress to analyze cell adhesion
Traction forces exerted by endothelial cells
Control of endothelial cell adhesion by mechanotransmission
PART III. ENGINEERED BIOMIMETIC SURFACES
Realistic atomistic modeling of protein adsorption to ceramic biomaterials
Cell responses to micro- and nano-topography
