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The Inhibitor Index is a curated collection of nearly 8000 enzyme inhibitors, receptor antagonists, drugs, toxins, poisons, biologics, and therapeutic leads. Written to inform and to foster judicious research, its single-volume format should make it the go-to reference.
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List of contents
No TOC, it is an alphabetical listing of compounds.
About the author
Dan Purich earned his Ph.D. for ground-breaking work on brain hexokinase, adenine nucleotide control, and multisubstrate inhibitors under Herbert Fromm at Iowa State University. After investigating the glutamine synthetase adenylylation cascade as an NIH Staff Fellow under Earl Stadtman, he joined the Chemistry Department at UC Santa Barbara. Awarded a Sloan Fellowship in Chemistry and NIH Research Career Development Award, Purich rose to full professor before moving to the University of Florida College of Medicine to become Chair of Biochemistry & Molecular Biology. He served on the Journal of Biological Chemistry, Archives of Biochemistry & Biophysics, and Biophysical Chemistry editorial boards. He also edited the six-volume Enzyme Kinetics & Mechanism sub-series of Methods in Enzymology and wrote The Handbook of Biochemical Kinetics (2000), The Enzyme Reference (2002), and Enzyme Kinetics: Catalysis & Control (2010). Author of over 170 peer-reviewed papers, chapters and reviews on enzyme action and cytoskeleton self-assembly, Purich discovered the actoclampins, the (+)-end-tracking motors that power actin-based motility by harnessing the Gibbs energy of on-filament ATP hydrolysis, while catalyzing monomer insertion. For fun, he travels and writes mystery novels.
Summary
The Inhibitor Index is a curated collection of nearly 8000 enzyme inhibitors, receptor antagonists, drugs, toxins, poisons, biologics, and therapeutic leads. Written to inform and to foster judicious research, its single-volume format should make it the go-to reference. .
Additional text
"Purich has compiled this handy reference tool listing approximately 7,800 biologically significant molecules that inhibit the action of enzymes or block cellular receptors...The list of targets enables laboratory researchers to choose the most specific and selective inhibitors or blockers for their experiments, and to remain alert to off-target effects. This unique desk reference will be useful for advanced undergraduate students, graduate students, and researchers devising laboratory research in cellular biochemistry and new drug development."
-CHOICE, February 2018 Vol. 55 No. 6
