Synthesis and identification of new derivatives of L-ascorbic acid - derivatives of L-ascorbic acid

In this work, three new derivatives (ligands) of L-ascorbic acid (vitamin C) and their metal complexes have been synthesized and characterized. The first ligand is Bis[O,O-2,3;O,O-5,6-(N,N-dicarboxylicmethylidene)-N-2-methylene pyridyl]-L-ascorbic acid (LP), was synthesized by the reaction of Bis[O,O-2,3;O,O-5,6-(chloro(carboxylic)methylidene)]-L-ascorbicacid (starting material) with one mmole 2-Picolylamine. The second ligand is Bis[O,O-2,3;O,O-5,6-(thiol(carboxylic)methylidene)]-L-ascorbic acid (LS), was synthesized by the reaction of Bis[O,O-2,3;O,O-5,6-(chloro (carboxylic)methylidene)]-L-ascorbic with excess of sodium sulfide. The third ligand is Bis[O,O-2,3;O,O-5,6-(acetate(carboxylic) methylidene)]-L-ascorbic acid (LA), was performed by the reaction of Bis[O,O-2,3;O,O-5,6-(chloro (carboxylic)methylidene)]-L-ascorbic acid with two mmoles sodium acetate and The biological activities of these ligands LP, LS, LA and some of their complexes which are (Co2+, Cu2+, Cd2+) performed against two types of pathogenic bacteria are Staphylococcus aureus (Gram Positive) and Escherichia coli (Gram Negative) in a nutrient agar medium.

About the author

Dr.Fazwi Yaha Faculty of Science, University of Kufa

Product details

• Authors: Huda A F AL-Bayti, Huda A. F. AL-Bayti, Huda A.F. AL-Bayti, Fali H Musa, Falih H Musa, Falih H. Musa, Falih H. Musa, Fazw Yahya, Fazwi Yahya
• Publisher: Scholar's Press
• Languages: English, German
• Product format: Paperback / Softback
• Released: 01.01.2016
• EAN: 9783659844416
• ISBN: 978-3-659-84441-6
• No. of pages: 184
• Subject: Natural sciences, medicine, IT, technology > Chemistry > Inorganic chemistry