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Informationen zum Autor Dr. Jeffery Cummings is an internationally recognized leader in clinical trials and drug development for neurodegenerative disorders. His work has been features in major peer-reviewed journals and his books have been influential world-wide. His work has garnered many awards.Dr. Jagan Pillai trained as a medical doctor at the University of Kerala, Trivandrum, India, obtained his PhD from Northwestern University, and pursued Residency in Neurology at the Albert Einstein College of Medicine. Dr. Pillai was closely involved in helping people with memory disorders and cognitive behavioral changes from neurodegenerative diseases. As a young scholar, Dr. Pillai further developed in research in Alzheimer's dementia and Huntington's disease. Dr. Pillai joined the Lou Ruvo Center for Brain Health in January 2012. He now works to help people with cognitive changes from neurological disorders and to develop diagnostic and treatment strategies for people with cognitive difficulties from neurodegenerative diseases. Klappentext Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is themain theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal isto accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases. Zusammenfassung As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research.Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases.This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story. Inhaltsverzeichnis Table of Contents List of Contributors 1 Neurodegenerative Diseases: Evolving Unifying Principles Jeffrey Cummings and Jagan Pillai 2 Neurodegenerative Diseases as Protein Misfolding Disorders Tomohiro Nakamura and Stuart A. Lipton 3 Calcium Hypothesis on Neurodegeneration: The Case of AD and HD Daniel A. Ryskamp, Elena Popugaeva, and Ilya Bezprozvanny 4 Neuroinflammation and Neurode...
