The Synthesis of an Internal Standard for Bicalutamide

(R,S)-Bicalutamide [N-(4-cyano-3-trifluoromethylphenyl)- -methyl- -hydroxy-beta-(4- fluorophenylsulfonyl)propanamide], sold as Casodex®, is the leading antiandrogen currently used to treat prostate cancer. It binds to androgen receptors and blocks cancer growth. This work aims to develop internal standards for the bio-analytical component of clinical trials that are required to detect bicalutamide and derivatives. An internal standard is added to the body fluid sample (mostly blood) at the beginning of the sample work up at about the same concentration of the analyte to be quantified. An ideal internal standard has a similar extraction recovery and a similar retention time in HPLC. For quantification with mass spectrometry it should have a difference of at least 3 mass units from the analyte and a similar ionization response. The internal standard is used to calibrate the total ion current of the metabolite.

About the author

Dr Maryam Amra Jordaan is associated in research and academics at Mangosuthu University of Technology in Durban. She completed her BSc in Chemistry and Physiology in 2004, her BSc Hons Chemistry in 2005,her MSc Medicinal Chemistry in 2008 and her PhD in 2013. Her current research focus is the development of alternative drug delivery systems for HIV

Product details

• Authors: Maryam Amr Jordaan, Maryam Amra Jordaan, Jan van der Westhuizen, Jan van der Westhuizen
• Publisher: LAP Lambert Academic Publishing
• Languages: English
• Product format: Paperback / Softback
• Released: 20.10.2016
• EAN: 9783659954313
• ISBN: 978-3-659-95431-3
• No. of pages: 148
• Dimensions: 150 mm x 220 mm x 9 mm
• Weight: 214 g
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Non-fiction book > Nature, technology > Natural science