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Comprehensive review of current research concerning how bacteria evade immunity and hence cause infection.
List of contents
Preface; Part I. Recognition of Bacteria: 1. The dendritic cell in bacterial infection: sentinel or Trojan horse? Benjamin M. Chain; 2. CD1 and non-peptide recognition systems in microbial immunity Kayvan R. Niazi, Steven A. Porcelli and Robert L. Modlin; 3. The NRAMP family: co-evolution of a host/pathogen defence system Richard Bellamy; Part II. Evasion of Humoral Immunity: 4. Evasion of complement pathways by bacteria Michael A. Kerr and Brian Henderson; 5. Bacterial immunoglobulin-evading mechanisms: Ig degradation and Ig-binding proteins Mogens Killian; 6. Evasion of antibody responses: bacterial phase variation Nigel J. Saunders; Part III. Evasion of Cellular Immunity: 7. Type III protein secretion and resistance to phagocytosis Ake Forsberg, Roland Rosqvist and Maria Fallman; 8. Bacterial superantigens and immune evasion John Fraser, Thomas Proft, Vickery Arcus and Edward Baker; 9. Density-dependent bacterial signalling molecules as immune modulators David Pritchard, Doreen Hooi, Eleanor Watson, Sek Chow, Gary Telford, Barrie Bycroft, Siri Ram Chhabra, Christopher Harty, Miguel Camara, Stephen Diggle and Paul Williams; 10. Microbial modulation of cytokine networks B. Henderson and Rob M. Seymour; 11. Enterotoxins: adjuvants and immune inhibitors Jan-Michael Klapproth and Michael S. Donnenberg; 12. Type III protein secretion and inhibition of NF-¿B Klaus Ruckdeschel, Bruno Rouot and Jürgen Heesemann.
Summary
Over the past decade researchers have shown that bacteria have evolved many ways of evading immunity and hence causing infection. Our present understanding of these mechanisms is described in this book, which will appeal to graduate students and researchers in microbiology, immunology, as well as in pharmacology and molecular medicine.
