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Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.
List of contents
Fungal Secondary Metabolites in the "OMICS" Era.- Key Players in the Regulation of Fungal Secondary Metabolism.- Epigenetics of Fungal Secondary Metabolism Related Genes.- Genome Mining for Fungal Secondary Metabolic Gene Clusters.- Metagenomics and Metatranscriptomics for the Exploration of Natural Products from Soil Fungi.- Metabolomics and Secondary Metabolite Profiling of Filamentous Fungi.- Fungal Chemotaxonomy.- Endophytic Fungi as a Source of Novel Metabolites.- Fungal Secondary Metabolism in the Light of Animal-FungusInteractions: From Mechanism to Ecological Function.- Fusarium Mycotoxins and Their Role in Plant-Pathogen Interactions.- Biosynthesis and Molecular Genetics of Peptaibiotics - Fungal Peptides Containing Alpha, Alpha - Dialkyl Amino Acids.
About the author
Juan-Francisco Martín, PhD
University of León, Department of Molecular Biology, Area of Microbiology, León, Spain
Carlos García-Estrada, DVM, PhD
Institute of Biotechnology of León (INBIOTEC), Parque Científico de León, León, Spain
Susanne Zeilinger, PhD
Vienna University of Technology, Institute of Chemical Engineering, Vienna, Austria
Summary
Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.
