Pre-Analytics of Pathological Specimens in Oncology

This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase - the period from surgical removal of tissue to the start of pathological processing - have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.

List of contents

What Is Pre-Analytics in Surgical Pathology? .- Histologic Validation of Vacuum Sealed Formalin.- Free Tissue Preservation and Transport System .- Pre-Analytics and Molecular Pathology.- Experiences in Vacuum Preparation of Routine Specimens.- Tissue Heterogeneity as a Pre-Analytical Source of Variability.- Vacuum Fixation of Breast Specimens Before Grossing.- How Do Short Fixation and Rapid Microwave Processing Affect Her2 Testing?.- Current Projects in Pre-Analytics - Where to Go?.- Nucleic Acid Extraction from FFPE Tissue as Critical Preanalytic Step for NGS Applications.- Experiences With Pre-Analytics of Lung Specimen.- Experiences With Pre-Analytics of GI-Specimen.- Bone Marrow Work-Up.- Two-Temperature Fixation Preserves Activation Status with High Efficiency.- Towards the Lean Lab. The Industry Challenge.

Product details

• Assisted by: Gianni Bussolati (Editor), Gianni Bussolati et al (Editor), Manfred Dietel (Editor), Moritz von Winterfeld (Editor), Moritz Winterfeld (Editor), Moritz von Winterfeld (Editor), Christia Wittekind (Editor), Christian Wittekind (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2016
• EAN: 9783319349824
• ISBN: 978-3-31-934982-4
• No. of pages: 133
• Dimensions: 155 mm x 7 mm x 235 mm
• Weight: 225 g
• Illustrations: VI, 133 p. 65 illus., 61 illus. in color.
• Series: Recent Results in Cancer Research; Recent Results in Cancer Research
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Chirurgie, B, Medicine, Surgery, Medizinische Forschung, Pathology, INTERNAL MEDICINE, Oncology, Biomedical Research, Medical laboratory testing & techniques, Laboratory Medicine